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製品番号: HY-112255

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J9

J9 is a small molecule that reverses Dexamethasone (HY-14648) resistance in T-cell acute lymphoblastic leukemia. J9 is lethal to CUTLL1 cells only in the presence of Dexamethasone. J9 inhibits CUTLL1 cell growth with an EC₅₀ of 28 μM in combination with Dexamethasone.

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CAS 番号: 947018-15-7
分子式: C₁₂H₁₂N₄
分子量:212.25

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

J9 構造式

CAS 番号: 947018-15-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
CUTLL1	EC₅₀	28 μM Compound: 1, J9	Growth inhibition of human CUTLL1 cells in presence of 1 uM dexamethasone after 48 hrs by alamar blue assay Growth inhibition of human CUTLL1 cells in presence of 1 uM dexamethasone after 48 hrs by alamar blue assay	[PMID: 25050160]
CUTLL1	EC₅₀	≥100 μM Compound: 1, J9	Growth inhibition of human CUTLL1 cells in absence of 1 uM dexamethasone after 48 hrs by alamar blue assay Growth inhibition of human CUTLL1 cells in absence of 1 uM dexamethasone after 48 hrs by alamar blue assay	[PMID: 25050160]

化学情報

CAS 番号 947018-15-7
分子量 212.25
分子式 C₁₂H₁₂N₄
SMILES

NC1=NC=C(C2=CC=NC=C2)C(C3CC3)=N1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Cantley AM, et al. Small Molecule that Reverses Dexamethasone Resistance in T-cell Acute Lymphoblastic Leukemia (T-ALL). ACS Med Chem Lett. 2014 Apr 25;5(7):754-9. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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