KKII5
Based on 1 Customer Validation
KKII5 is a potent Lipoxygenase (LOX-1) inhibitor with an IC50 of 19 μM. KKII5 inhibits lipid peroxidation.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.60%
- CAS 番号: 6381-55-1
- 分子式: C16H14N2S
- 分子量:266.36
-
保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
Immunology/Inflammation Compound Library
HY-L007
-
Metabolism/Protease Compound Library
HY-L012
-
Ferroptosis Compound Library
HY-L051
-
Lipid Metabolism Compound Library
HY-L091
-
Metabolic Enzyme Compound Library
HY-L146
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
Anti-Fibrosis Compound Library
HY-L185
-
High-Throughput Bioactive Compound Library
HY-L205
生物活性
IC50: 19 μM (LOX-1)[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
>10 μM
Compound: 5
|
Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as inhibition of 5H-dibenzo[b,e]azepine-10-carboxylic acid methyl ester-induced increase in intracellular calcium by Fluo4-AM based fluorometric assay
Antagonist activity at human TRPA1 expressed in HEK293 cells assessed as inhibition of 5H-dibenzo[b,e]azepine-10-carboxylic acid methyl ester-induced increase in intracellular calcium by Fluo4-AM based fluorometric assay
|
[PMID: 22222037] |
KKII5 interacts with HIS499 of the cavity by forming one π–π stacking interaction between the phenyl ring of the molecule and the imidazole ring of HIS499[1].
KKII5 (100 μM) strongly inhibits lipid peroxidation with 98% inhibition[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 6381-55-1
-
性状 Solid
-
分子量 266.36
-
分子式 C16H14N2S
-
Color White to off-white
-
SMILES
C1=CC=C(C=C1)C2C=C(NC(=S)N2)C3=CC=CC=C3
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (375.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (273 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7543 mL | 18.7716 mL | 37.5432 mL | 93.8579 mL |
| 5 mM | 0.7509 mL | 3.7543 mL | 7.5086 mL | 18.7716 mL | |
| 10 mM | 0.3754 mL | 1.8772 mL | 3.7543 mL | 9.3858 mL | |
| 15 mM | 0.2503 mL | 1.2514 mL | 2.5029 mL | 6.2572 mL | |
| 20 mM | 0.1877 mL | 0.9386 mL | 1.8772 mL | 4.6929 mL | |
| 25 mM | 0.1502 mL | 0.7509 mL | 1.5017 mL | 3.7543 mL | |
| 30 mM | 0.1251 mL | 0.6257 mL | 1.2514 mL | 3.1286 mL | |
| 40 mM | 0.0939 mL | 0.4693 mL | 0.9386 mL | 2.3464 mL | |
| 50 mM | 0.0751 mL | 0.3754 mL | 0.7509 mL | 1.8772 mL | |
| 60 mM | 0.0626 mL | 0.3129 mL | 0.6257 mL | 1.5643 mL | |
| 80 mM | 0.0469 mL | 0.2346 mL | 0.4693 mL | 1.1732 mL | |
| 100 mM | 0.0375 mL | 0.1877 mL | 0.3754 mL | 0.9386 mL |
KKII5 関連分類
HY-W488004 関連分類
Powered by Bioz