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KY-1044

(別名: Alomfilimab; SAR 445256)
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Based on 1 Customer Validation

KY-1044 (Alomfilimab; SAR 445256) is a fully human IgG1 antibody targeting inducible costimulatory receptor (ICOS). KY-1044 depletes ICOShigh cells via antibody-dependent cellular cytotoxicity (ADCC) through the engagement of FcgRIIIa. KY-1044 act as a costimulatory molecule on cells expressing lower ICOS levels, such as CD8+ TEff cells (through FcgR-dependent clustering). KY-1044 exploit the differential expression of ICOS on T-cell subtypes to improve the intratumoral immune contexture and restore an antitumor immune response.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

  • 純度: 99.51%
  • CAS 番号: 2489390-15-8
  • 分子量:146.5 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for KY-1044
  • Experimental Validation Results for KY-1044
  • Experimental Validation Results for KY-1044
  • KY-1044 Chemical Structure
    KY-1044 構造式
CAS 番号: 2489390-15-8
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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KY-1044 おすすめ製品:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized ICOS Protein, Human can bind Alomfilimab. The EC50 for this effect is 11.35 ng/mL.

  • 1/16

    Flow Cytometry analysis of Jurkat cells labelling ICOS/CD278 (red) with KY-1044 (anti-ICOS/CD278) (HY-P99431). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001).

  • KY-1044 Chemical Structure
    1/16
  • KY-1044
  • Immobilized ICOS Protein, Human can bind Alomfilimab. The EC50 for this effect is 11.35 ng/mL.
  • Flow Cytometry analysis of Jurkat cells labelling ICOS/CD278 (red) with KY-1044 (anti-ICOS/CD278) (HY-P99431). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001).