LC-U7-44
LC-U7-44 is a potent USP7 inhibitor with an IC50 of 0.96 μM. LC-U7-44 binds to the hydrophobic catalytic pocket of USP7, forming hydrogen bonds with Gln297, Arg408, Asp295, Val296, and Gln351, and hydrophobic interactions with Leu406. LC-U7-44 exerts anti-proliferative effects on prostate cancer cells. LC-U7-44 can be used for the research of prostate cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C28H32N6O3
- 分子量:500.59
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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USP7 0.96 μM (IC50) |
LC-U7-44 (10 μM; 20-30 min) potently inhibits purified USP7 protein with an IC50 of 0.96 μM in a fluorescence polarization binding assay[1].
LC-U7-44 potently inhibits the enzymatic activity of purified USP7 protein with an IC50 of 0.46 μM in a Ub-Rho assay[1].
LC-U7-44 (0.01-100 μM; 6 days) potently inhibits the proliferation of LNCaP cells with an IC50 of 1.83 μM following 6 days of treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:lymph node carcinoma of the prostate (LNCaP) cells
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Concentration:0.01-100 μM
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Incubation Time:6 days
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Result:Suppressed LNCaP cell proliferation with an IC50 of 1.83 μM.
化学情報
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分子量 500.59
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分子式 C28H32N6O3
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SMILES
CN1N=C2C(N=CN(CC3(O)CCN(C(CCC4=CC=CC=C4)=O)CC3)C2=O)=C1C5=CC=C(CN)C=C5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
LC-U7-44 関連分類
HY-183282 関連分類
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