LCKLSL
Based on 8 publication(s) in Google Scholar
LCKLSL is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL also inhibits the generation of plasmin and has anti-angiogenic roles.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.26%
- CAS 番号: 533902-29-3
- 分子式: C30H57N7O8S
- 分子量:675.88
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 LCKLSL
More- J Extracell Vesicles. 2024 Apr;13(4):e12425. [Abstract]
- J Immunother Cancer. 2025 Jun 26;13(6):e011716. [Abstract]
- Cell Commun Signal. 2024 Dec 21;22(1):616. [Abstract]
- Biomed Pharmacother. 2023 Mar:159:114173. [Abstract]
- Biochem Pharmacol. 2025 Sep 6;242(Pt 2):117308. [Abstract]
- Inflamm Res. 2022 Sep;71(9):1067-1078. [Abstract]
- iScience. 2025 Apr 2;28(5):112302. [Abstract]
- J Neurochem. 2022 Mar;160(6):662-674. [Abstract]
Customer Validation & Images
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WB
生物活性
Annexin A2 (AnxA2)[1]
In human retinal microvascular endothelial cells (RMVECs), treatment with LCKLSL (0-2 mg) inhibits the generation of plasmin and suppresses the VEGF-induced activity of tPA under hypoxic conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 533902-29-3
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性状 Solid
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分子量 675.88
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分子式 C30H57N7O8S
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Color White to off-white
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配列
Leu-Cys-Lys-Leu-Ser-Leu
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シーケンスの短縮
LCKLSL
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (8)
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Journal Impact Factor
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Most Recent
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J Extracell Vesicles
2024 Apr;13(4):e12425. PMID: 38594791 -
J Immunother Cancer
Targeting Annexin A2 to reactivate tumor-associated antigens presentation and relieve immune tolerance in liver cancer. [Abstract]2025 Jun 26;13(6):e011716. PMID: 40571481 -
Cell Commun Signal
Exosomal ANXA2 facilitates ovarian cancer peritoneal metastasis by activating peritoneal mesothelial cells through binding with TLR2. [Abstract]2024 Dec 21;22(1):616. PMID: 39709496 -
Biomed Pharmacother
Isoliquiritigenin alleviates the development of alcoholic liver fibrosis by inhibiting ANXA2. [Abstract]2023 Mar:159:114173. PMID: 36680814
LCKLSL purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2023 Mar:159:114173. [Abstract]
LCKLSL (5 μM) intervention significantly inhibits ANXA2 protein expression levels when compare to the alcohol group, in activated HSC-T6 cells.
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Biochem Pharmacol
Isoliquiritigenin inhibits the activation of the ANXA2/STAT3 pathway by down-regulating TAGLN2, thereby alleviating alcoholic fatty liver. [Abstract]2025 Sep 6;242(Pt 2):117308. PMID: 40921221 -
Inflamm Res
Inhibition of ANXA2 regulated by SRF attenuates the development of severe acute pancreatitis by inhibiting the NF-κB signaling pathway. [Abstract]2022 Sep;71(9):1067-1078. PMID: 35900381 -
iScience
Humanized mouse model reveals T cell ANXA2 as a potential therapeutic target in ischemic stroke. [Abstract]2025 Apr 2;28(5):112302. PMID: 40641552 -
J Neurochem
Activation of Annexin A2 signaling at the blood-brain barrier in a mouse model of multiple sclerosis. [Abstract]2022 Mar;160(6):662-674. PMID: 35064931
溶剤 & 溶解度
H2O : ≥ 50 mg/mL (73.98 mM)
DMSO : 5 mg/mL (7.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (254 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.4796 mL | 7.3978 mL | 14.7955 mL | 36.9888 mL |
| 5 mM | 0.2959 mL | 1.4796 mL | 2.9591 mL | 7.3978 mL | |
| H2O | 10 mM | 0.1480 mL | 0.7398 mL | 1.4796 mL | 3.6989 mL |
| 15 mM | 0.0986 mL | 0.4932 mL | 0.9864 mL | 2.4659 mL | |
| 20 mM | 0.0740 mL | 0.3699 mL | 0.7398 mL | 1.8494 mL | |
| 25 mM | 0.0592 mL | 0.2959 mL | 0.5918 mL | 1.4796 mL | |
| 30 mM | 0.0493 mL | 0.2466 mL | 0.4932 mL | 1.2330 mL | |
| 40 mM | 0.0370 mL | 0.1849 mL | 0.3699 mL | 0.9247 mL | |
| 50 mM | 0.0296 mL | 0.1480 mL | 0.2959 mL | 0.7398 mL | |
| 60 mM | 0.0247 mL | 0.1233 mL | 0.2466 mL | 0.6165 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
LCKLSL 関連分類
HY-P2333 関連分類
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