Ledol
Based on 1 Customer Validation
Ledol ((+)-Ledol) is an antifungal agent isolated from the volatile oil components of Rhododendron tomentosum. Ledol also acts as an expectorant and antitussive, while it can cause adverse reactions such as dizziness, nausea and vomiting.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.0%
- CAS 番号: 577-27-5
- 分子式: C15H26O
- 分子量:222.37
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BV-2 | IC50 |
>50 μM
Compound: 15
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Antineuroinflammatory activity against mouse BV-2 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess assay
Antineuroinflammatory activity against mouse BV-2 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess assay
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[PMID: 34978437] |
体外実験
Ledol (1500 ng per band; 2 min at 100°C) is detectable as a dark blue band (Rf = 0.40) via qualitative HPTLC in essential oils from intact R. tomentosum plant material, but is absent in essential oils from R. tomentosum in vitro microshoot cultures[1].
Ledol (1500 ng per band; 30 min dark incubation) does not exhibit DPPH free radical scavenging activity under the tested conditions[1].
Ledol (1500 ng per band; 10 min fluorescent light exposure) does not exhibit superoxide scavenging activity under the tested conditions[1].
Ledol (1500 ng per band; 20 min at 38°C) does not exhibit xanthine oxidase inhibitory activity under the tested conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 577-27-5
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性状 Solid
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分子量 222.37
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分子式 C15H26O
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Color White to off-white
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SMILES
O[C@@]1(C)CC[C@@]2([H])[C@@](C2(C)C)([H])[C@@]3([H])[C@@H](C)CC[C@@]13[H]
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別名
(+)-Ledol
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMF : ≥ 50 mg/mL (224.85 mM)
DMSO : 12.5 mg/mL (56.21 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Jesionek A, et al. Validated HPTLC method for determination of ledol and alloaromadendrene in the essential oil fractions of Rhododendron tomentosum plants and in vitro cultures and bioautography for their activity screening. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jun 1;1086:63-72. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / DMF | 1 mM | 4.4970 mL | 22.4850 mL | 44.9701 mL | 112.4252 mL |
| 5 mM | 0.8994 mL | 4.4970 mL | 8.9940 mL | 22.4850 mL | |
| 10 mM | 0.4497 mL | 2.2485 mL | 4.4970 mL | 11.2425 mL | |
| 15 mM | 0.2998 mL | 1.4990 mL | 2.9980 mL | 7.4950 mL | |
| 20 mM | 0.2249 mL | 1.1243 mL | 2.2485 mL | 5.6213 mL | |
| 25 mM | 0.1799 mL | 0.8994 mL | 1.7988 mL | 4.4970 mL | |
| 30 mM | 0.1499 mL | 0.7495 mL | 1.4990 mL | 3.7475 mL | |
| 40 mM | 0.1124 mL | 0.5621 mL | 1.1243 mL | 2.8106 mL | |
| 50 mM | 0.0899 mL | 0.4497 mL | 0.8994 mL | 2.2485 mL | |
| DMF | 60 mM | 0.0750 mL | 0.3748 mL | 0.7495 mL | 1.8738 mL |
| 80 mM | 0.0562 mL | 0.2811 mL | 0.5621 mL | 1.4053 mL | |
| 100 mM | 0.0450 mL | 0.2249 mL | 0.4497 mL | 1.1243 mL |
Ledol 関連分類
HY-121388 関連分類
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