Lergotrile
Lergotrile is a potent and orally active dopamine agonist and a prolactin secretion inhibitor. Lergotrile inhibits prolactin release from pituitaries by activating an adenohypophyseal dopamine receptor. Lergotrile has the potential for the research of Parkinson's disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 36945-03-6
- 分子式: C17H18ClN3
- 分子量:299.80
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Dopamine Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sympathetic neuron | ED50 |
0.27 μM/kg
Compound: 2
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Compound tested in vivo for sympathetic neuronal activity in cat cardioaccelerator nerve after iv administration
Compound tested in vivo for sympathetic neuronal activity in cat cardioaccelerator nerve after iv administration
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[PMID: 6699883] |
| Sympathetic neuron | ED50 |
0.27 μmol/Kg
Compound: 2
|
Compound tested in vivo for sympathetic neuronal activity in cat cardioaccelerator nerve after iv administration
Compound tested in vivo for sympathetic neuronal activity in cat cardioaccelerator nerve after iv administration
|
[PMID: 6699883] |
化学情報
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CAS 番号 36945-03-6
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分子量 299.80
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分子式 C17H18ClN3
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SMILES
ClC1=C2C3=C(N1)C=CC=C3[C@]4([H])[C@@](N(C[C@@H](C4)CC#N)C)([H])C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Clemens JA, et al. Inhibition of prolactin secretion by lergotrile mesylate: mechanism of action. Acta Endocrinol (Copenh). 1975 Jun;79(2):230-7. [Content Brief]
[2]. Lemberger L, et al. The inhibitory effect of an ergoline derivative (lergotrile, compound 83636) on prolactin secretion in man. J Clin Endocrinol Metab. 1974 Sep;39(3):579-84. [Content Brief]
[3]. Lieberman A, et al. Treatment of Parkinson's disease with lergotrile mesylate. JAMA. 1977 Nov 28;238(22):2380-2. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Lergotrile 関連分類
HY-107002 関連分類
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