M‑89
Based on 1 Customer Validation
M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin. M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to study MLL leukemia. M-89 inhibits the cell growth in leukemia cell lines carrying MLL fusion.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.14%
- CAS 番号: 2363165-42-6
- 分子式: C37H47N5O4S
- 分子量:657.87
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
Kd: 1.4 nM (menin)[1].
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
10.2 μM
Compound: 42; M-89
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Growth inhibition of human HL60 cells after 4 days by WST-8 assay
Growth inhibition of human HL60 cells after 4 days by WST-8 assay
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[PMID: 31244110] |
| MOLM-13 | IC50 |
0.054 μM
Compound: 42; M-89
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Growth inhibition of human MOLM13 cells after 4 days by WST-8 assay
Growth inhibition of human MOLM13 cells after 4 days by WST-8 assay
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[PMID: 31244110] |
| MV4-11 | IC50 |
0.025 μM
Compound: 42; M-89
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Growth inhibition of human MV4-11 cells after 4 days by WST-8 assay
Growth inhibition of human MV4-11 cells after 4 days by WST-8 assay
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[PMID: 31244110] |
体外実験
M-89 inhibits the cell growth of MV4;11 cell line with an IC50 of 25 nM[1].
M-89 inhibits the cell growth of HL-60 cell line with an IC50 of 10.2 μM[1].
M-89 (3.7-300 nM) stabilized the cellular menin protein in both MV4;11 and MOLM-13 cells dose-dependently[1].
M-89 (0.03-3 μM, 48 h) induces a time- and dose-dependent apoptosis in MV4;11 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2363165-42-6
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性状 Solid
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分子量 657.87
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分子式 C37H47N5O4S
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Color White to off-white
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SMILES
O=C(NC)O[C@@H]1[C@@H]([C@]2(C3CCN(CC4CN(C5=CC=C(S(=O)(C6=CC=NC=C6)=O)C=C5)C4)CC3)CN(C)CC7=C2C=CC=C7)CCC1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
溶剤 & 溶解度
体外:
DMSO : 7.35 mg/mL (11.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5201 mL | 7.6003 mL | 15.2006 mL | 38.0014 mL |
| 5 mM | 0.3040 mL | 1.5201 mL | 3.0401 mL | 7.6003 mL | |
| 10 mM | 0.1520 mL | 0.7600 mL | 1.5201 mL | 3.8001 mL |
M‑89 関連分類
HY-128347 関連分類
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