MDL12330A
Based on 6 publication(s) in Google Scholar
MDL12330A (RMI12330A) is an adenylyl cyclases inhibitor. MDL12330A can inhibit KV channels, increases insulin secretion and Ca2+ levels. MDL12330A accentuates contractions in uterine rings and inhibits cardiac functions. MDL12330A can be used for the research of endocrinology, metabolic and cardiovascular disease .
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.82%
- CAS 番号: 40297-09-4
- 分子式: C23H37ClN2
- 分子量:377.01
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保管条件:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 MDL12330A
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生物活性
MDL12330A (10 μM) increases insulin secretion and produces prolonged APDs in pancreatic beta cells[1].
MDL-12,330A (10 μM) inhibits KV channels and increases Ca2+ levels in pancreatic beta cells[1].
MDL12330A (10 μM, 30 min) accentuates contractions in uterine rings from rats at mid gestation but not at term gestation or at term gestation in labor[2].
MDL12330A inhibits all cardiac functions in isolated active hearts of guinea pigs with an IC50 of 1.1 μM, including contractile force, dP/dt, dF/dt, pressure development, and activity performance[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 40297-09-4
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性状 Solid
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分子量 377.01
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分子式 C23H37ClN2
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Color White to off-white
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SMILES
[H]Cl.C1(/N[C@@H]2[C@H](C3=CC=CC=C3)CCC2)=N/CCCCCCCCCCC1
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別名
RMI12330A
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (6)
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Journal Impact Factor
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Most Recent
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Cell Host Microbe
Enterococcus faecalis-derived lactic acid suppresses macrophage activation to facilitate persistent and polymicrobial wound infections. [Abstract]2026 Feb 11;34(2):245-262.e8. PMID: 41605216 -
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Andrology
Cellular mechanism underlying leptin-induced anion secretion of rat epididymal epithelial cells. [Abstract]2024 May 22. PMID: 38778669 -
Cytotechnology
Exploring the laxative effects of emodin on constipation through chloride channel activation. [Abstract]2026 Jun;78(3):104. PMID: 42083655 -
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溶剤 & 溶解度
DMSO : 20 mg/mL (53.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Okawa T, et al. Role of nucleotide cyclases in the inhibition of pregnant rat uterine contractions by the openers of potassium channels. Am J Obstet Gynecol. 2000;182(4):913-918. [Content Brief]
[2]. Li X, et al. The adenylyl cyclase inhibitor MDL-12,330A potentiates insulin secretion via blockade of voltage-dependent K(+) channels in pancreatic beta cells. PLoS One. 2013;8(10):e77934. Published 2013 Oct 29. [Content Brief]
[3]. Grupp G, et al. Effects of RMI 12330A, a new inhibitor of adenylate cyclase on myocardial function and subcellular activity. Br J Pharmacol. 1980 Nov;70(3):429-42. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6524 mL | 13.2622 mL | 26.5245 mL | 66.3112 mL |
| 5 mM | 0.5305 mL | 2.6524 mL | 5.3049 mL | 13.2622 mL | |
| 10 mM | 0.2652 mL | 1.3262 mL | 2.6524 mL | 6.6311 mL | |
| 15 mM | 0.1768 mL | 0.8841 mL | 1.7683 mL | 4.4207 mL | |
| 20 mM | 0.1326 mL | 0.6631 mL | 1.3262 mL | 3.3156 mL | |
| 25 mM | 0.1061 mL | 0.5305 mL | 1.0610 mL | 2.6524 mL | |
| 30 mM | 0.0884 mL | 0.4421 mL | 0.8841 mL | 2.2104 mL | |
| 40 mM | 0.0663 mL | 0.3316 mL | 0.6631 mL | 1.6578 mL | |
| 50 mM | 0.0530 mL | 0.2652 mL | 0.5305 mL | 1.3262 mL |
MDL12330A 関連分類
HY-103192 関連分類
Powered by Bioz
- MDL12330A
- 40297-09-4
- RMI12330A
- Adenylate Cyclase
- Potassium Channel
- adenylate cyclase
- cyclic adenosine monophosphate
- mid-gestation uterine rings
- insulin secretion
- voltage-dependent Ca2+ channels
- potassium channel
- voltage-dependent K+ (KV) channels
- pancreatic beta cells
- uterine tissue
- uterine contractility
- Inhibitor
- inhibitor
- inhibit