MK-8527
Based on 1 Customer Validation
MK-8527 is an orally active HIV inhibitor and nucleoside reverse transcriptase translocation inhibitor (NRTTI) with antiviral activity. MK-8527 has a similar inhibitory mechanism to ISL (HY-104012).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.99%
- CAS 番号: 1810869-23-8
- 分子式: C13H13ClN4O3
- 分子量:308.72
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
MK-8527 causes loss of lymphocytes[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 1810869-23-8
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性状 Solid
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分子量 308.72
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分子式 C13H13ClN4O3
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Color White to off-white
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SMILES
OC[C@]1(C#C)[C@@H](O)C[C@H](N2C3=NC(Cl)=NC(N)=C3C=C2)O1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (323.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Gillespie SW, et al. Islatravir: evaluation of clinical development for HIV and HBV. Expert Opin Investig Drugs. 2024 Feb;33(2):85-93. [Content Brief]
[2]. Liu AY, et al. CROI 2024: Global Epidemiology and Prevention of HIV and Other Sexually Transmitted Diseases. Top Antivir Med. 2024 Jul 17;32(3):447-482. [Content Brief]
[3]. Gunaratne SH, et al. CROI 2024: The Challenges of Sustained Viral Suppression, Advanced HIV Disease, and Ending the HIV Epidemic Targets. Top Antivir Med. 2024 Aug 12;32(4):542-567. [Content Brief]
[4]. Zhernov YV, et al. Microbicides for Topical HIV Immunoprophylaxis: Current Status and Future Prospects. Pharmaceuticals (Basel). 2024 May 22;17(6):668. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2392 mL | 16.1959 mL | 32.3918 mL | 80.9795 mL |
| 5 mM | 0.6478 mL | 3.2392 mL | 6.4784 mL | 16.1959 mL | |
| 10 mM | 0.3239 mL | 1.6196 mL | 3.2392 mL | 8.0980 mL | |
| 15 mM | 0.2159 mL | 1.0797 mL | 2.1595 mL | 5.3986 mL | |
| 20 mM | 0.1620 mL | 0.8098 mL | 1.6196 mL | 4.0490 mL | |
| 25 mM | 0.1296 mL | 0.6478 mL | 1.2957 mL | 3.2392 mL | |
| 30 mM | 0.1080 mL | 0.5399 mL | 1.0797 mL | 2.6993 mL | |
| 40 mM | 0.0810 mL | 0.4049 mL | 0.8098 mL | 2.0245 mL | |
| 50 mM | 0.0648 mL | 0.3239 mL | 0.6478 mL | 1.6196 mL | |
| 60 mM | 0.0540 mL | 0.2699 mL | 0.5399 mL | 1.3497 mL | |
| 80 mM | 0.0405 mL | 0.2024 mL | 0.4049 mL | 1.0122 mL | |
| 100 mM | 0.0324 mL | 0.1620 mL | 0.3239 mL | 0.8098 mL |
MK-8527 関連分類
HY-158128 関連分類
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