Monarsen
Monarsen (EN101) is a synthetic 20-base antisense oligodeoxynucleotide directed against the human AChE gene. Monarsen is used in the study of Autoimmune myasthenia gravis (MG), a neuromuscular disorder caused by autoantibodies directed against the acetylcholine receptor (AChR).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 864021-55-6
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
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AChE |
化学情報
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CAS 番号 864021-55-6
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SMILES
[Monarsen]
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別名
EN101; ODN 7040; BL 7040
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配列
DNA, d(C-T-G-C-G-A-T-A-T-T-T-T-C-T-T-G-T-rAm-rCm-rCm)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Sussman JD, Argov Z, McKee D, Hazum E, Brawer S, Soreq H. Antisense treatment for myasthenia gravis: experience with monarsen. Ann N Y Acad Sci. 2008;1132:283-290. [Content Brief]
[2]. Evron T, Moyal-Segal LB, Lamm N, Geffen A, Soreq H. RNA-targeted suppression of stress-induced allostasis in primate spinal cord neurons. Neurodegener Dis. 2005;2(1):16-27. [Content Brief]
[3]. Kehat R, Zemel E, Cuenca N, et al. A novel isoform of acetylcholinesterase exacerbates photoreceptors death after photic stress. Invest Ophthalmol Vis Sci. 2007;48(3):1290-1297. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)