Monascorubrin
Based on 1 Customer Validation
Monascorubrin is a compound that can be isolated from Monascus mycelia. Monascorubrin has activities such as anti-inflammatory, anti-tumor, antibacterial, and immunomodulatory. Monascorubrin also has certain embryotoxicity, with an ED50 of 4.3 μg for chicken embryos. Monascorubrin can be used for the research of tumors and inflammatory diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.0%
- CAS 番号: 13283-90-4
- 分子式: C23H26O5
- 分子量:382.45
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保管条件:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
130.89 μM
Compound: 8
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Antiproliferative activity against human A431 cells after 72 hrs
Antiproliferative activity against human A431 cells after 72 hrs
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[PMID: 20655237] |
| IGROV-1 | IC50 |
102.88 μM
Compound: 8
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Antiproliferative activity against human IGROV1 cells after 72 hrs
Antiproliferative activity against human IGROV1 cells after 72 hrs
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[PMID: 20655237] |
| NCI-H460 | IC50 |
>50 μM
Compound: 8
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Antiproliferative activity against human NCI-H460 cells after 72 hrs
Antiproliferative activity against human NCI-H460 cells after 72 hrs
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[PMID: 20655237] |
Monascorubrin (0.2-1 mg/mL; 24 h) inhibits the growth of Candida pseudotropicalis and Bacillus subtilis[1].
Monascorubrin (10-5000 ng/well; 96-well plate; 6 h) shows weak inhibitory effect on the proliferation of Concanavalin A (HY-P2149)-stimulated mouse T-splenocytes, but significantly increases the intracellular calcium concentration in T-splenocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female ICR mice treated TPA (HY-18739) and DMBA (HY-W011845)[2]
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Dosage:2 μmol
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Administration:Topical application; twice a week; 18 weeks
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Result:Significantly suppressed TPA-induced tumor promotion, with the first tumor appearing at week 8 (vs. week 6 in control), 7% tumor-bearing mice at week 18 (vs. 100% in control), and an average of 0.1 tumors per mouse at week 18 (vs. 10.6 in control), representing a 99% reduction.
化学情報
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CAS 番号 13283-90-4
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性状 Solid
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分子量 382.45
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分子式 C23H26O5
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Color Yellow to orange
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SMILES
O=C(O1)C(C(CCCCCCC)=O)=C2[C@]1(C)C(C3=COC(/C=C/C)=CC3=C2)=O
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Structure Classification
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Initial Source
Monascus purpureus
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : 25 mg/mL (65.37 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. L Martínková, et al. Biological activities of oligoketide pigments of Monascus purpureus. Food Addit Contam. 1999 Jan;16(1):15-24. [Content Brief]
[2]. Yasukawa K, et al. Azaphilones inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mice. Oncology. 1994 Jan-Feb;51(1):108-12. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6147 mL | 13.0736 mL | 26.1472 mL | 65.3680 mL |
| 5 mM | 0.5229 mL | 2.6147 mL | 5.2294 mL | 13.0736 mL | |
| 10 mM | 0.2615 mL | 1.3074 mL | 2.6147 mL | 6.5368 mL | |
| 15 mM | 0.1743 mL | 0.8716 mL | 1.7431 mL | 4.3579 mL | |
| 20 mM | 0.1307 mL | 0.6537 mL | 1.3074 mL | 3.2684 mL | |
| 25 mM | 0.1046 mL | 0.5229 mL | 1.0459 mL | 2.6147 mL | |
| 30 mM | 0.0872 mL | 0.4358 mL | 0.8716 mL | 2.1789 mL | |
| 40 mM | 0.0654 mL | 0.3268 mL | 0.6537 mL | 1.6342 mL | |
| 50 mM | 0.0523 mL | 0.2615 mL | 0.5229 mL | 1.3074 mL | |
| 60 mM | 0.0436 mL | 0.2179 mL | 0.4358 mL | 1.0895 mL |
Monascorubrin 関連分類
HY-N8492 関連分類
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