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製品番号: HY-157932

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MR24

MR24, a G-5555 (HY-19635) derivative, is a mammalian STE20-like (MST) kinase inhibitor. MR24 shows selectively to MST3/4 over MST1/2, with EC₅₀ values of 57 and 583 nM, respectively. MR24 induces G1 phase cell cycle arrest. MR24 can be used for cancer research, such as breast, liver and lung cancers.

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CAS 番号: 3056814-89-9
分子式: C₂₆H₂₉ClN₆O₃
分子量:509.00

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

MR24 構造式

CAS 番号: 3056814-89-9

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

MST3

57 nM (EC₅₀)

MST4

583 nM (EC₅₀)

Hippo (MST) アイソフォーム固有の製品をすべて表示 :

体外実験

MR24 (compound 24) (1-10 μM, 6-72 h) shows no significant effect on cell healthy nuclei in HCT116 cells, and only results in a slight reduction in cell viability by about 30% at a concentration of 10 μM^[1].
MR24 (1-10 μM, 24-72 h) induces G1 phase cell cycle arrest in HCT116 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

HCT116 cells
Concentration:

1, 5, and 10 μM
Incubation Time:

24, 48 and 72 h
Result:

Increased the fraction of cells in the G1 phase at 10 μM.

Cell Viability Assay^[1]

Cell Line:

HCT116 cells
Concentration:

1 and 10 μM
Incubation Time:

6, 12, 24, 48 and 72 h
Result:

Showed no significant effect on the normalized cell count at a concentration of 1 μM.
Resulted in a slight reduction in cell viability by about 30% at a concentration of 10 μM.
Resulted in over 90% healthy nuclei after 24 h at both concentrations used (1 and 10 μM).

化学情報

CAS 番号 3056814-89-9
分子量 509.00
分子式 C₂₆H₂₉ClN₆O₃
SMILES

CC1=CC=CC(C2=CC(Cl)=C(C=C2)C3=CC4=C(N(C3=O)CCCCN)N=C(N=C4)NC(CO)CO)=N1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Marcel Rak, et al. Development of Selective Pyrido[2,3-d]pyrimidin-7(8H)-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors. J. Med. Chem. 2024.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
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MR24

Hippo (MST) アイソフォーム固有の製品をすべて表示