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製品番号: HY-115273

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MRS-2179

2 Cited Publications

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

MRS-2179 is a selective and competitive antagonist for P2Y1 receptor, with K_B of 0.177 μM.

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CAS 番号: 101204-49-3
分子式: C₁₁H₁₇N₅O₉P₂
分子量:425.23

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

MRS-2179 構造式

CAS 番号: 101204-49-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
Publications (2)
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

MRS-2179 is a selective and competitive antagonist for P2Y1 receptor, with K_B of 0.177 μM^[1].

IC₅₀ & Target

P2Y1 Receptor

P2Y Receptor アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
COS-7	IC₅₀	210 nM Compound: MRS-2179	Inhibition concentration required against wild type strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]-MRS2279 as radioligand Inhibition concentration required against wild type strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]-MRS2279 as radioligand	[PMID: 15481977]
COS-7	IC₅₀	320 nM Compound: MRS-2179	Inhibition concentration required against human Y306A mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand Inhibition concentration required against human Y306A mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand	[PMID: 15481977]
COS-7	IC₅₀	330 nM Compound: MRS-2179	Inhibition concentration required against human Y203F mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand Inhibition concentration required against human Y203F mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand	[PMID: 15481977]
COS-7	IC₅₀	480 nM Compound: MRS-2179	Inhibition concentration required against human Y273A mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]-MRS2279 as radioligand Inhibition concentration required against human Y273A mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]-MRS2279 as radioligand	[PMID: 15481977]
COS-7	IC₅₀	660 nM Compound: MRS-2179	Inhibition concentration required against human Y273F mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand Inhibition concentration required against human Y273F mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand	[PMID: 15481977]
COS-7	IC₅₀	740 nM Compound: MRS-2179	Inhibition concentration required against human Y203A (EL2) mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand Inhibition concentration required against human Y203A (EL2) mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand	[PMID: 15481977]
COS-7	IC₅₀	980 nM Compound: MRS-2179	Inhibition concentration required against human Y306F mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand Inhibition concentration required against human Y306F mutant strain P2Y1 receptor expressed in COS-7 cells is determined using [3H]MRS2279 as radioligand	[PMID: 15481977]
Oocyte	EC₅₀	>10000 nM Compound: MRS-2179	Antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 10 uM, expressed in Xenopus oocytes Antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 10 uM, expressed in Xenopus oocytes	[PMID: 12213051]
Oocyte	EC₅₀	>10000 nM Compound: MRS-2179	Antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) at 3 uM, expressed in Xenopus oocytes Antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) at 3 uM, expressed in Xenopus oocytes	[PMID: 12213051]
Oocyte	EC₅₀	13 μM Compound: MRS-2179	The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 30 uM, expressed in Xenopus oocytes The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 30 uM, expressed in Xenopus oocytes	[PMID: 12213051]

化学情報

CAS 番号 101204-49-3
分子量 425.23
分子式 C₁₁H₁₇N₅O₉P₂
SMILES

CNC1=C2C(N([C@@H]3O[C@H](CO[P](O)(O)=O)[C@@H](O[P](O)(O)=O)C3)C=N2)=NC=N1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Journal Impact Factor

Mil Med Res

PANX1-mediated ATP release confers FAM3A's suppression effects on hepatic gluconeogenesis and lipogenesis. [Abstract]

2024 Jun 27;11(1):41. PMID: 38937853
Int J Biol Macromol

Sibanin, a novel black fly-derived Kunitz protease inhibitor, prevents thrombus formation in mice by anticoagulation-antiplatelet duality. [Abstract]

2025 Mar:296:139766. PMID: 39800030

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Moro S, et al., Human P2Y1 receptor: molecular modeling and site-directed mutagenesis as tools to identify agonist and antagonist recognition sites. J Med Chem. 1998 Apr 23;41(9):1456-66. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MRS-2179

2 Cited Publications

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生物活性
- 製品説明
- IC₅₀ & Target
化学情報
Publications (2)
純度とドキュメンテーション
参考文献

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MRS-2179

MedChemExpress（MCE）の使用を引用している文献 MRS-2179

P2Y Receptor アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (2)

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

MRS-2179 関連分類

HY-115273 関連分類