NDM-622
NDM-622 is a Colistin (HY-113678) adjuvant. NDM-622 weakly inhibits IKKβ with an IC50 of 20.40 μM. NDM-622 reduces the minimum inhibitory concentration of colistin against colistin-highly-resistant Acinetobacter baumannii and Klebsiella pneumoniae. NDM-622 decreases bacterial colony-forming units in a mouse peritonitis model infected with colistin-highly-resistant Klebsiella pneumoniae. NDM-622 does not modify bacterial lipid A, induce reactive oxygen species production, or increase bacterial membrane permeability. NDM-622 can be used in the research of extensively drug-resistant Gram-negative bacterial infections, colistin-resistant Acinetobacter baumannii infections, and Klebsiella pneumoniae infections.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C15H8F6INO2
- 分子量:475.12
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
IKKβ 20.40 μM (IC50) |
体外実験
NDM-622 (2-10 μM; 16-20 h) potently enhances the activity of Colistin (HY-113678) against Colistin-resistant Acinetobacter baumannii AB4106 and Klebsiella pneumoniae KPB9, and reduces the MIC of Colistin by up to 4096-fold at a concentration of 10 μM[1].
NDM-622 (5 μM; 1 h) does not enhance the cell membrane permeability of colistin-resistant Acinetobacter baumannii AB4106; at a dose of 5 μM, it only causes a slight and statistically insignificant increase in the permeability of colistin-resistant Klebsiella pneumoniae KPB9[1].
NDM-622 (24 h) exhibits low toxicity against hepatocellular carcinoma cell line HepG2, with an IC50 value of 125 μM[1].
NDM-622 (pre-incubated for 30 min) weakly inhibits IκB kinase-β in HEK293-NFκB-Luc cells, with an IC50 of 20.40 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:129S6/SvEvTac (male and female, 6-7 months old, cyclophosphamide-induced immunosuppression)[1]
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Dosage:50 mg/kg
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Administration:i.p.; 3 doses (0.25 hours pre-inoculation, 1 hour post-inoculation, 2.5 hours post-inoculation)
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Result:Produced a statistically significant reduction in Klebsiella pneumoniae B9 colony forming units (CFUs) recovered from the peritoneal cavity compared to control mice treated with colistin plus vehicle.
化学情報
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分子量 475.12
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分子式 C15H8F6INO2
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SMILES
O=C(NC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)C2=CC(O)=C(I)C=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NDM-622 関連分類
HY-184325 関連分類
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Keywords
- NDM-622
- NDM622
- NDM 622
- Bacterial
- IKK
- IκB kinase
- I kappa B kinase
- HepG2 human liver cancer cells
- Klebsiella pneumoniae
- liver cells
- HEK293-NFκB-Luc cells
- extensively drug-resistant gram-negative bacterial infections
- murine peritonitis model
- Acinetobacter baumannii
- IκB kinase-β
- mcr-1-harboring isolates
- colistin-resistant Acinetobacter baumannii infection
- Inhibitor
- inhibitor
- inhibit