Norbaeocystin
Norbaeocystin is an intermediate/minor metabolite naturally present in the psilocybin biosynthetic pathway of hallucinogenic mushrooms (Psilocybe spp.). Norbaeocystin has weak or no affinity for the serotonin 2A (5-HT2A) receptor and does not induce receptor activation. Norbaeocystin is rapidly metabolized by monoamine oxidase, and thus does not participate in centrally mediated psychedelic effects. Norbaeocystin can be used for studies on biological pathways associated with hallucinogenic effects.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 21420-59-7
- 分子式: C10H13N2O4P
- 分子量:256.19
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Long-Evans (male, adult, PND 90-120)[1]
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Dosage:0.13 mg/kg; 0.25 mg/kg; 1.26 mg/kg; 2.52 mg/kg (broth vehicle); 0.1 mg/kg; 0.2 mg/kg; 1.0 mg/kg; 2.0 mg/kg (distilled water vehicle)
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Administration:p.o.; single dose
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Result:Failed to increase the rate of head twitch responses at any dose tested in either vehicle.
Showed no significant effect across doses in broth vehicle.
Showed no significant effect across doses in water vehicle.
Had no significant effect on locomotor behavior (total distance travelled or rearing events).
化学情報
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CAS 番号 21420-59-7
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分子量 256.19
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分子式 C10H13N2O4P
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SMILES
O=P(O)(OC1=CC=CC2=C1C(CCN)=CN2)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Adams AM, et al. Development of an -based norbaeocystin production platform and evaluation of behavioral effects in rats. Metabolic engineering communications. 2022 Jun;14:e00196. [Content Brief]
[2].
Sherwood AM, et al. Synthesis and Biological Evaluation of Tryptamines Found in Hallucinogenic Mushrooms: Norbaeocystin, Baeocystin, Norpsilocin, and Aeruginascin. J Nat Prod. 2020 Feb 28;83(2):461-467.
[Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Norbaeocystin 関連分類
HY-168809 関連分類
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- Norbaeocystin
- 21420-59-7
- Drug Intermediate
- 5-HT Receptor
- monoamine oxidase
- tryptamine biosynthetic substrate
- male Long-Evans rats
- 4-hydroxyindole
- hallucinogenic effect-related biological pathways
- serotonin 2A (5-HT2A) receptor
- rats
- recombinant E. coli BL21 Star? (DE3) strain Nor1
- blood-brain barrier
- Inhibitor
- inhibitor
- inhibit