NOS-IN-2
NOS-IN-2 (Compound 4i) is a potent, selective, imidamide derived NOS inhibitor with an IC50 against iNOS of 20 µM, without inhibiting eNOS. NOS-IN-2 has little toxicity and can be used for studying inflammatory disorders.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2766146-79-4
- 分子式: C18H20F3N3O2
- 分子量:367.37
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
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iNOS 20 μM (IC50) |
nNOS >1000 μM (IC50) |
体外実験
NOS-IN-2 (Compound 4i) shows high iNOS selectivity without eNOS inhibition activity [1].
NOS-IN-2 (0-100 µM, 30 min) has little toxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HUVECs
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Concentration:10, 20, 50, 100, 500 µM
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Incubation Time:30 min
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Result:Had little toxicity, only at the concentration above 100 µM, the cell viability was significantly (approximately 20%) reduced.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2766146-79-4
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分子量 367.37
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分子式 C18H20F3N3O2
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SMILES
COC1=CC=C(C(C(CCNC(C2=CC=C(C=C2)C(F)(F)F)=N)O)=C1)N
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NOS-IN-2 関連分類
HY-115916 関連分類
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