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製品番号: HY-165616

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NS 1231

NS 1231 is a neurotrophic-like compound with neuroprotective effect. NS 1231 can rescue nerve growth factor (NGF)-differentiated PC12 cells from death induced by withdrawal of trophic factors. NS 1231 can stimulate NGF-induced neurite outgrowth of undifferentiated PC12 cells. NS 1231 can be used for the research of neurological disease, such as stroke.

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CAS 番号: 309711-72-6
分子式: C₁₈H₁₅ClN₂O₂
分子量:326.78

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

NS 1231 構造式

CAS 番号: 309711-72-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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製品説明

Trk Receptor アイソフォーム固有の製品をすべて表示 :

体外実験

NS 1231 (1-10 μM) increases the viability of NGF-differentiated PC12 cells and preserves the neurites of surviving cells when administered for 4 days after trophic factor (serum and NGF) withdrawal^[1].
NS 1231 (1-3 μM, 48 h) in combination with NGF significantly stimulates neurite outgrowth in undifferentiated PC12 cells^[1].
NS 1231 (1-3 μM, 5 mins) in combination with NGF enhances NGF-induced TrkA phosphorylation at the Shc-binding site (Tyr490) and ERK activation (Thr202/Tyr204) in undifferentiated PC12 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

NS 1231 (15 mg/kg, i.p., 2 mins after MCAO) reduces the total infarct volume in mice with middle cerebral artery occlusion (MCAO)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice with middle cerebral artery occlusion (MCAO)^[1]
Dosage:

15 mg/kg
Administration:

Intraperitoneally injection, 2 mins after MCAO
Result:

Reduced the total infarct volume by 43% after 4 days.

化学情報

CAS 番号 309711-72-6
分子量 326.78
分子式 C₁₈H₁₅ClN₂O₂
SMILES

O=C1NC2=C(C=C(C3=CC=C(Cl)C=C3)C4=C2CCCC4)/C1=N/O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Dagø L, et al. NS 1231, a novel compound with neurotrophic-like effects in vitro and in vivo. J Neurochem. 2002 Apr;81(1):17-24. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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参考文献

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NS 1231

Trk Receptor アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

NS 1231 関連分類

HY-165616 関連分類