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製品番号: HY-146424

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OBHS

OBHS is an estrogen receptor α (ERα) inhibitor. OBHS can also be used as a blowing agent.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 870614-18-9
分子式: C₂₄H₂₀O₆S
分子量:436.48

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

OBHS 構造式

CAS 番号: 870614-18-9

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

OBHS is an estrogen receptor α (ERα) inhibitor. OBHS can also be used as a blowing agent^[1]^[2].

Estrogen Receptor/ERR アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	>100 μM Compound: OBHS	Antiproliferative activity against human DU145 cells assessed as inhibition of cell viability after 72 hrs by MTT assay Antiproliferative activity against human DU145 cells assessed as inhibition of cell viability after 72 hrs by MTT assay	[PMID: 25993269]
HEK-293T	EC₅₀	0.095 μM Compound: OBHS	Agonist activity at ER-alpha (unknown origin) transfected in HEK293T cells assessed as stimulation of transcriptional activity after 24 hrs by luciferase reporter gene assay Agonist activity at ER-alpha (unknown origin) transfected in HEK293T cells assessed as stimulation of transcriptional activity after 24 hrs by luciferase reporter gene assay	[PMID: 25993269]
HEK-293T	IC₅₀	0.014 μM Compound: OBHS	Antagonist activity at ER-alpha (unknown origin) transfected in HEK293T cells assessed as inhibition of transcriptional activity after 24 hrs by luciferase reporter gene assay Antagonist activity at ER-alpha (unknown origin) transfected in HEK293T cells assessed as inhibition of transcriptional activity after 24 hrs by luciferase reporter gene assay	[PMID: 25993269]
HEK-293T	IC₅₀	0.581 μM Compound: OBHS	Antagonist activity at ER-beta (unknown origin) transfected in HEK293T cells assessed as inhibition of transcriptional activity after 24 hrs by luciferase reporter gene assay Antagonist activity at ER-beta (unknown origin) transfected in HEK293T cells assessed as inhibition of transcriptional activity after 24 hrs by luciferase reporter gene assay	[PMID: 25993269]
MCF7	IC₅₀	20.9 μM Compound: OBHS	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability after 72 hrs by MTT assay	[PMID: 25993269]
Vero	IC₅₀	>100 μM Compound: OBHS	Antiproliferative activity against african green monkey Vero cells assessed as inhibition of cell viability after 72 hrs by MTT assay Antiproliferative activity against african green monkey Vero cells assessed as inhibition of cell viability after 72 hrs by MTT assay	[PMID: 25993269]

化学情報

CAS 番号 870614-18-9
分子量 436.48
分子式 C₂₄H₂₀O₆S
SMILES

O=S([C@H]1C[C@@H]2C(C3=CC=C(C=C3)O)=C([C@H]1O2)C4=CC=C(C=C4)O)(OC5=CC=CC=C5)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. He M, et al. Design, synthesis and biological evaluation of novel dual-acting modulators targeting both estrogen receptor α (ERα) and lysine-specific demethylase 1 (LSD1) for treatment of breast cancer. Eur J Med Chem. 2020 Jun 1;195:112281. [Content Brief]

[2]. Srikham J, et al. Foamability of Natural rubber (NR)/Poly (butylenes adipate-co-terephthalate)(PBAT) Thermoplastic Vulcanizate with OBSH as a blowing agent. 2020 IOP Conf. Ser.: Mater. Sci. Eng. 965 012018.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
化学情報
純度とドキュメンテーション
参考文献

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OBHS

Estrogen Receptor/ERR アイソフォーム固有の製品をすべて表示