Oleyl alcohol
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Oleyl alcohol is an anti-tumor compound that inhibits tumor growth. Oleyl alcohol induces cytotoxicity, cell death and apoptosis. The intracellular accumulation of Oleyl alcohol correlates with its cytotoxicity against tumor cells. Oleyl alcohol forms enhancer-enriched fluid domains in stratum corneum lipids, increases the retention of diclofenac diethylamine in ex vivo human epidermis and dermis, and enhances the skin permeability of diclofenac diethylamine. Oleyl alcohol can be used in studies related to neuroblastoma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.00%
- CAS 番号: 143-28-2
- 分子式: C18H36O
- 分子量:268.48
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保管条件:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Oleyl alcohol (5-50 μg/mL; 24 h) induces dose-dependent cytotoxicity in human neuroblastoma HTLA-230 cells, with PSO 2% 10:1 complexes showing the highest potency (IC50 = 10.1 μg/mL) and PSO 3% 3:1 complexes showing the lowest potency (IC50 = 41.6 μg/mL) after 24 h of treatment[1].
Oleyl alcohol (0.75% w/v; 24-48 h) increases DIC-DEA permeation through ex vivo human skin 2.8-fold after a single 24 h dose and 2.7-fold after four repeated doses over 48 h[3].
Oleyl alcohol (0.75% w/v; 24 h) does not adversely affect TEWL or electrical impedance of ex vivo human skin, with all barrier effects fully reversible within 24 h after sample removal[3].
Oleyl alcohol (0.75% w/v; 8-24 h) does not fluidize ex vivo human SC lipid chains after 8 or 24 h of application, forms fluid enhancer-rich domains in SC lipids after 24 h[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human neuroblastoma HTLA-230 cell line
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Concentration:5-50 μg/mL
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Incubation Time:24 h
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Result:Induced dose-dependent cell death, with cytotoxicity correlating with release rates.
Reached an IC50 of 10.1 μg/mL for PSO 2% 10:1 complexes.
Reached an IC50 of 12.7 μg/mL for PSO 2% 5:1 complexes.
Reached an IC50 of 15.6 μg/mL for PSO 2% 3:1 complexes.
Reached an IC50 of 24.4 μg/mL for PSO 3% 10:1 complexes.
Reached an IC50 of 30.3 μg/mL for PSO 3% 5:1 complexes.
Reached an IC50 of 41.6 μg/mL for PSO 3% 3:1 complexes.
Showed no cytotoxicity for pure polymers at concentrations up to 500 μg/mL.
化学情報
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CAS 番号 143-28-2
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性状 Liquid (Density: 0.8489 g/cm³)
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分子量 268.48
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分子式 C18H36O
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Color Colorless to light yellow
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SMILES
CCCCCCCC/C=C\CCCCCCCCO
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : ≥ 30 mg/mL (111.74 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (267 KB)
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SDS (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Orienti I, et al. Enhancement of oleyl alcohol anti tumor activity through complexation in polyvinylalcohol amphiphilic derivatives. Drug delivery. 2007 Apr;14(4):209-17. [Content Brief]
[3]. Kováčik A, et al. Time-Dependent Differences in the Effects of Oleic Acid and Oleyl Alcohol on the Human Skin Barrier. Molecular pharmaceutics. 2023 Dec 04;20(12):6237-6245. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7247 mL | 18.6234 mL | 37.2467 mL | 93.1168 mL |
| 5 mM | 0.7449 mL | 3.7247 mL | 7.4493 mL | 18.6234 mL | |
| 10 mM | 0.3725 mL | 1.8623 mL | 3.7247 mL | 9.3117 mL | |
| 15 mM | 0.2483 mL | 1.2416 mL | 2.4831 mL | 6.2078 mL | |
| 20 mM | 0.1862 mL | 0.9312 mL | 1.8623 mL | 4.6558 mL | |
| 25 mM | 0.1490 mL | 0.7449 mL | 1.4899 mL | 3.7247 mL | |
| 30 mM | 0.1242 mL | 0.6208 mL | 1.2416 mL | 3.1039 mL | |
| 40 mM | 0.0931 mL | 0.4656 mL | 0.9312 mL | 2.3279 mL | |
| 50 mM | 0.0745 mL | 0.3725 mL | 0.7449 mL | 1.8623 mL | |
| 60 mM | 0.0621 mL | 0.3104 mL | 0.6208 mL | 1.5519 mL | |
| 80 mM | 0.0466 mL | 0.2328 mL | 0.4656 mL | 1.1640 mL | |
| 100 mM | 0.0372 mL | 0.1862 mL | 0.3725 mL | 0.9312 mL |
Oleyl alcohol 関連分類
HY-141573 関連分類
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