Oxonantenine
Oxonantenine is an isoquinoline alkaloid isolated from the seeds of Nandina domestica that exhibits cytotoxicity against cancer cells. Oxonantenine binds to proteins associated with the MAPK and NF-κB signaling pathways, including JUN, MAPK1, p38, MAPK3, ERK, JNK3, and p65. Oxonantenine is one of the main components of Fangji Huangqi Tang. Oxonantenine can be used in studies related to non-small cell lung cancer and rheumatoid arthritis.
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- CAS 番号: 15358-38-0
- 分子式: C19H13NO5
- 分子量:335.31
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[2]|
JNK3 |
体外実験
Oxonantenine (8.15 μM; 48 h) potently inhibits the viability of A549 cells with an IC50 of 8.15 μM[1].
Oxonantenine potently binds to MAPK/NF-κB signaling pathway-related proteins (JUN, MAPK1, p38, MAPK3, ERK, JNK3, p65) with binding energies ranging from -33.39 to -44.61 kcal/mol, indicating stable target interactions[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 15358-38-0
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分子量 335.31
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分子式 C19H13NO5
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SMILES
O=C1C2=NC=CC3=CC(OC)=C(C(C4=C1C=C5OCOC5=C4)=C23)OC
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Qin J, et al. Two new isoquinoline alkaloids from the seeds of Nandina domestica. Nat Prod Res. 2021 Oct;35(19):3254-3260. [Content Brief]
[2]. Zhang W, et al. Network Pharmacology-Based Strategy Integrated with Molecular Docking and In Vitro Experimental Validation to Explore the Underlying Mechanism of Decoction in Treating Rheumatoid Arthritis. ACS omega. 2024 Jul 23;9(29):31878-31889. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Oxonantenine 関連分類
HY-N19654 関連分類
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