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Pasritamig

(別名: JNJ-78278343; KLCB-245)
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Based on 1 Customer Validation

Pasritamig (JNJ-78278343; KLCB-245) is a bispecific T-cell engager (BiTE) that targets the complex of human kallikrein KLK2 and CD3 receptor. Pasritamig redirects the cytotoxicity of T cells to KLK2-expressing tumor cells and induces T cell-mediated lysis of KLK2-expressing prostate cancer cells. Administered via subcutaneous injection, subcutaneous infusion or intravenous infusion, Pasritamig exhibits antitumor activity against metastatic castration-resistant prostate cancer. Pasritamig has a safety profile with an extremely low incidence of cytokine release syndrome and can be safely administered in an outpatient setting. Pasritamig is applicable to the research of metastatic castration-resistant prostate cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

  • 純度: 97.76%
  • CAS 番号: 2921676-04-0
  • 分子量:124.81 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Pasritamig
  • Experimental Validation Results for Pasritamig
  • Experimental Validation Results for Pasritamig
  • Experimental Validation Results for Pasritamig
  • Pasritamig Chemical Structure
    Pasritamig 構造式
CAS 番号: 2921676-04-0
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    G1-kappa_scFv-h-CH2-CH3

  • 1/16

    Immobilized Kallikrein-2 Protein, Human (HEK293, His, HY-P70317) can bind Pasritamig. The EC50 for this effect is 53.53 ng/mL.

  • 1/16

    Immobilized CD3 epsilon Protein, Human (HEK293, His,HY-P70506) can bind Pasritamig. The EC50 for this effect is 791.3 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 Juakat cells with Pasritamig (HY-P991015, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Pasritamig Chemical Structure
    1/16
  • Pasritamig
  • Immobilized Kallikrein-2 Protein, Human (HEK293, His, HY-P70317) can bind Pasritamig. The EC50 for this effect is 53.53 ng/mL.
  • Immobilized CD3 epsilon Protein, Human (HEK293, His,HY-P70506) can bind Pasritamig. The EC50 for this effect is 791.3 ng/mL.
  • Flow cytometric analysis of 1X106 Juakat cells with Pasritamig (HY-P991015, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • G1-kappa_scFv-h-CH2-CH3