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製品番号: HY-W679796

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PBITC

(別名: 4-Phenylbutyl isothiocyanate)

PBITC (4-Phenylbutyl isothiocyanate) is an orally active antitumor agent, and inhibits NNK (HY-126477) induced lung tumors in mice. PBITC is a thio-analog of the apoptosis inducer ISC-4 (HY-118375).

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CAS 番号: 61499-10-3
分子式: C₁₁H₁₃NS
分子量:191.29

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

PBITC 構造式

CAS 番号: 61499-10-3

容量

価格（税別）

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数量

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

PBITC (4-Phenylbutyl isothiocyanate) is an orally active antitumor agent, and inhibits NNK (HY-126477) induced lung tumors in mice. PBITC is a thio-analog of the apoptosis inducer ISC-4 (HY-118375)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	IC₅₀	27 μM Compound: 1c, PBITC	Cytotoxicity against human Caco-2 cells after 72 hrs by MTS assay Cytotoxicity against human Caco-2 cells after 72 hrs by MTS assay	[PMID: 19053750]
HT-1080	IC₅₀	15 μM Compound: 1c, PBITC	Cytotoxicity against human HT1080 cells after 72 hrs by MTS assay Cytotoxicity against human HT1080 cells after 72 hrs by MTS assay	[PMID: 19053750]
MDA-MB-231	IC₅₀	27 μM Compound: 1c, PBITC	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTS assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTS assay	[PMID: 19053750]
PC-3	IC₅₀	24 μM Compound: 1c, PBITC	Cytotoxicity against human PC-3 cells after 72 hrs by MTS assay Cytotoxicity against human PC-3 cells after 72 hrs by MTS assay	[PMID: 19053750]
T98G	IC₅₀	35 μM Compound: 1c, PBITC	Cytotoxicity against human T98G cells after 72 hrs by MTS assay Cytotoxicity against human T98G cells after 72 hrs by MTS assay	[PMID: 19053750]
UACC-903	IC₅₀	16 μM Compound: 1c, PBITC	Cytotoxicity against human UACC-903 cells after 72 hrs by MTS assay Cytotoxicity against human UACC-903 cells after 72 hrs by MTS assay	[PMID: 19053750]

化学情報

CAS 番号 61499-10-3
分子量 191.29
分子式 C₁₁H₁₃NS
SMILES

S=C=NCCCCC1=CC=CC=C1
別名

4-Phenylbutyl isothiocyanate
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (263 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Melissa A. Gimbor, et al. Abstract LB-464: Phenylbutyl isoselenocyanate (ISC-4) and phenylbutyl isothiocyanate (PBITC) inhibit 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induced lung tumorigenesis in A/J mouse. Cancer Res (2011) 71 (8_Supplement): LB-464.

Calculators

モル濃度計算機

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濃度濃度

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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