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United States

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製品番号: HY-N3071

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Picrasidine I

Picrasidine I is an anti-inflammatory and anti-osteoclastogenic dimeric alkaloid that can be isolated from Picrasma quassioides. Picrasidine I inducs cell cycle arrest, and triggers cell apoptosis by downregulats ERK and Akt pathways. Picrasidine I inhibits the activation of MAPKs, NF-κB and ROS generation, and suppresses the expression of c-Fos and NFATc1.

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CAS 番号: 100234-59-1
分子式: C₁₄H₁₂N₂O₂
分子量:240.26

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Picrasidine I 構造式

CAS 番号: 100234-59-1

容量

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数量

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	8.47 μM Compound: 54	Antiproliferative activity against human A2780 cells Antiproliferative activity against human A2780 cells	[PMID: 34332400]
SK-OV-3	IC₅₀	16.28 μM Compound: 54	Antiproliferative activity against human SK-OV-3 cells Antiproliferative activity against human SK-OV-3 cells	[PMID: 34332400]

化学情報

CAS 番号 100234-59-1
分子量 240.26
分子式 C₁₄H₁₂N₂O₂
SMILES

OC1=CC=CC2=C1NC3=C2C(OC)=CN=C3C=C
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (274 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Ho HY, et al. Picrasidine I Triggers Heme Oxygenase-1-Induced Apoptosis in Nasopharyngeal Carcinoma Cells via ERK and Akt Signaling Pathways. Int J Mol Sci. 2022 May 29;23(11):6103. [Content Brief]

[2]. Kong L, et al. Picrasidine I from Picrasma Quassioides Suppresses Osteoclastogenesis via Inhibition of RANKL Induced Signaling Pathways and Attenuation of ROS Production. Cell Physiol Biochem. 2017;43(4):1425-1435. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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