PP185
PP185 is a insulin receptor kinase substrate. PP185 undergoes rapid tyrosine phosphorylation, with activity dependent on divalent cations and inhibited by insulin receptor kinase domain antibodies. PP185 can be used for the research of neuroblastoma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 851176-40-4
- 分子式: C11H14ClNO2
- 分子量:227.69
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
PP185 (0.4-200 μM; 1 h) engages an increasing number of cysteine sites in HEK293T cell lysates as its concentration increases, with detectable liganding events observed at higher concentrations[1].
PP185 is phosphorylated in a rapid and dose-dependent manner induced by both Insulin (HY-P0035) and IGF-I in mouse neuroblastoma N18 cells, with maximal phosphorylation at 1 min and rapid dephosphorylation thereafter[2].
PP185 from rat H-35 hepatoma cells has tyrosine phosphorylation in a cell-free system inhibited by anti-IRK (a site-specific antibody targeting insulin receptor kinase)[3].
PP185 in rat H-35 hepatoma cells undergoes rapid tyrosine phosphorylation induced by insulin treatment[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 851176-40-4
-
分子量 227.69
-
分子式 C11H14ClNO2
-
SMILES
O=C(N(C)CC=1C=CC=C(OC)C1)CCl
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Biggs GS,et al. Robust proteome profiling of cysteine-reactive fragments using label-free chemoproteomics. Nat Commun. 2025 Jan 2;16(1):73. [Content Brief]
[2]. Shemer J, et al. Insulin and insulin-like growth factor-I stimulate a common endogenous phosphoprotein substrate (pp185) in intact neuroblastoma cells. J Biol Chem. 1987;262(32):15476-15482. [Content Brief]
[3]. Tashiro-Hashimoto Y, et al. Tyrosine phosphorylation of pp185 by insulin receptor kinase in a cell-free system. J Biol Chem. 1989;264(12):6879-6885. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PP185 関連分類
HY-183840 関連分類
Powered by Bioz