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製品番号: HY-N10348A

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Progoitrin potassium

Progoitrin potassium is an orally active glucosinolate. As the precursor of goitrin (HY-N0224A), an antithyroid compound, progoitrin releases goitrin via hydrolysis by myrosinase or gastrointestinal glucosidase. Progoitrin converts to goitrin in vivo and exerts antithyroid activity by inhibiting the accumulation of radioactive iodine in the thyroid gland. Progoitrin potassium can be used in the research of Graves' disease (thyrotoxicosis).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 21087-77-4
分子式: C₁₁H₁₈KNO₁₀S₂
分子量:427.49

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Progoitrin potassium 構造式

CAS 番号: 21087-77-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Potassium progoitrin (1.4 μmol/g; 5-60 min at 150-200 °C) shows the lowest thermal stability in pH 9.0 phosphate buffer and undergoes thermal degradation to produce volatile flavor compounds^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Progoitrin (potassium) (20-1000 mg; p.o.; s.c.; i.p.; 1 to 23.5 hours before I¹³¹ injection) exhibits dose-dependent antithyroid activity in male Holtzman rats, with oral administration generally more potent than subcutaneous or intraperitoneal routes at equivalent doses, reducing thyroidal I¹³¹ uptake to as low as 31.8% of control values^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Holtzman rats (male, 100-120 gm)^[3]
Dosage:

20 mg; 200 mg; 300 mg; 625 mg; 1000 mg
Administration:

p.o.; s.c.; i.p.; 1 to 23.5 hours before I¹³¹ injection
Result:

Reduced thyroidal I¹³¹ uptake.

化学情報

CAS 番号 21087-77-4
分子量 427.49
分子式 C₁₁H₁₈KNO₁₀S₂
SMILES

C=C[C@H](O)C/C(S[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO)=N/OS(=O)(O[K])=O
Structure Classification
- Ketones, Aldehydes, Acids
- Glucosinolates
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Zhang Y, et al. Characterization of Thermally Induced Flavor Compounds from the Glucosinolate Progoitrin in Different Matrices via GC-TOF-MS. Journal of agricultural and food chemistry. 2022 Feb 02;70(4):1232-1240.

[2]. Collett MG, et al. Hepatotoxicity of Two Progoitrin-Derived Nitriles in New Zealand White Rabbits. Toxins. 2020 Nov 02;12(11):695. [Content Brief]

[3]. GREER MA, et al. Antithyroid activity elicited by the ingestion of pure progoitrin, a naturally occurring thioglycoside of the turnip family. J Clin Invest. 1959 Sep;38(9):1465-74. [Content Brief]

[4]. Liu Z, et al. Reducing progoitrin and enriching glucoraphanin in Brassica napus seeds through silencing of the GSL-ALK gene family. Plant molecular biology. 2012 May;79(1-2):179-89. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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