ProTx-III
ProTx-III is a selective and potent inhibitor of voltage-gated sodium channel Nav1.7, with an IC50 of 2.1 nM. ProTx-III is a spider venom peptide isolated from the venom of the Peruvian green velvet tarantella. ProTx-III has a typical inhibitor cystine knot motif (ICK). ProTx-III is able to reverse the pain response. ProTx-III can be used to study diseases such as chronic pain, epilepsy, and arrhythmia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1808297-63-3
- 分子式: C162H246N52O43S6
- 分子量:3802.40
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Nav1.7 2.1 nM (IC50) |
ProTx-III in native, recombinant and synthetic C-terminal acid and amide forms inhibit hNaV1.7 with IC50s of 2.1, 9.5, 11.5 and 2.5 nM, respectively[1].
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ProTx-III inhibits hNav1.7 without significantly altering the voltage dependence of activation or inactivation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:OD1-induced mouse model of pain(300Nm; intraplantar injection)[1]
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Dosage:100 nM, 300 nM, 1μM
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Administration:intraplantar injection
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Result:Showed at 1 μM (40 pmoles in a 40 μl injection) and 300 nM (12 pmoles in a 40 μl injection) significantly reduced spontaneous pain behaviour in a concentration dependent manner and this reduction in pain behaviour persisted for 25 min after injection of the highest concentration.
化学情報
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CAS 番号 1808297-63-3
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分子量 3802.40
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分子式 C162H246N52O43S6
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別名
μ-TRTX-Tp1a
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配列
Asp-Cys-Leu-Lys-Phe-Gly-Trp-Lys-Cys-Asn-Pro-Arg-Asn-Asp-Lys-Cys-Cys-Ser-Gly-Leu-Lys-Cys-Gly-Ser-Asn-His-Asn-Trp-Cys-Lys-Leu-His-Ile-NH2 (Disulfide bonds: Cys2-Cys17, Cys9-Cys22, Cys16-Cys29)
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シーケンスの短縮
DCLKFGWKCNPRNDKCCSGLKCGSNHNWCKLHI-NH2 (Disulfide bonds: Cys2-Cys17, Cys9-Cys22, Cys16-Cys29)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ProTx-III 関連分類
HY-P5153 関連分類
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