PU-20F
PU-20F is a Hsp90 inhibitor with an EC50 of 6.8 μM. PU-20F competes with Geldanamycin (HY-15230) for binding to Hsp90 and regulates the function of this molecular chaperone. PU-20F induces the degradation of oncogenic Her2 tyrosine kinase. PU-20F blocks the growth of breast cancer cells. PU-20F can be used in breast cancer-related research.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 422508-29-0
- 分子式: C20H24FN5O4
- 分子量:417.44
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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HSP90 6.8 μM (EC50) |
PU-20F (compound 59) competes with geldanamycin for binding to purified Hsp90 protein with an EC50 of 6.8 μM[1].
PU-20F (72 h) inhibits the growth of MCF-7 human breast cancer cells with an IC50 of 23 μM[1].
PU-20F induces degradation of Her2 tyrosine kinase in MCF-7 human breast cancer cells with an IC50 of 20 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 422508-29-0
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分子量 417.44
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分子式 C20H24FN5O4
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SMILES
FC=1N=C(N)C=2N=C(N(C2N1)CC3OCCC3)CC4=CC(OC)=C(OC)C(OC)=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PU-20F 関連分類
HY-121706 関連分類
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