PY-4Car2
PY-4Car2 is a Camptothecin (HY-16560) derivative and a topoisomerase I inhibitor. PY-4Car2 functions as a warhead conjugated via a cleavable linker to the bispecific ADC TJ101. PY-4Car2 can be used as an ADC payload for the research of cancers.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3054643-04-5
- 分子式: C29H30FN3O7
- 分子量:551.56
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保管条件:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
PY-4CAR2, when delivered via the bispecific dual-payload ADC TJ102 (co-formulated with PE-E2K), contributes to robust, selective cytotoxicity in ovarian and kidney cancer cell lines[1].
PY-4Car2, as the warhead of bispecific ADC TJ101, drives synergistic cytotoxicity in EGFR- and B7-H3-coexpressing solid cancer cell lines, with activity dependent on target antigen binding[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 3054643-04-5
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性状 Solid
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分子量 551.56
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分子式 C29H30FN3O7
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Color White to light yellow
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SMILES
OCCCCOC(N[C@@H]1C2=C3C(C(N4C3)=CC([C@](O)(C(OC5)=O)CC)=C5C4=O)=NC6=CC(F)=C(C)C(CC1)=C62)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
PY-4Car2 関連分類
HY-183912 関連分類
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