Rasburicase
Based on 1 publication(s) in Google Scholar
Rasburicase is a recombinant form of urate oxidase that works by catalyzing the oxidation of uric acid to allantoin, which has a higher solubility. Rasburicase specifically degrades uric acid, rapidly lowers blood uric acid levels, and improves inflammation and kidney damage caused by uric acid crystal deposition. Rasburicase can effectively lower uric acid and prevent uric acid nephropathy, and is used in the study of severe hyperuricemia associated with tumor lysis syndrome (TLS) and refractory gout.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 95%
- CAS 番号: 134774-45-1
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Rasburicase
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生物活性
Rasburicase (100 μg; intravenous injection; 3 times; days -3, 0, +3) inhibits anti-rasburicase antibody production in mice, reduces the number of splenic antigen-specific B cells and T cells, and upregulates the proportion of regulatory T cells (Treg)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c Nude Mouse Tumor Lysis Syndrome (TLS) Model (male, 18-22 g, 6-8 weeks old): TLS induced by chemotherapy[1]
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Dosage:0.2 mg/kg
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Administration:Intravenous injection, once daily for 5-7 days
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Result:Significantly reduced serum uric acid levels by 86%.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 134774-45-1
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性状 Lyophilized Powder
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Color White to off-white
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SMILES
[Rasburicase]
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Clin Invest
GLUT9b- and ABCG2-mediated collecting duct urate transport uncover a vasopressin-independent mechanism of renal water reabsorption. [Abstract]2026 Jun 16:e197021. PMID: 42298327
純度とドキュメンテーション
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データシート (269 KB)
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SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Korean - KR (418 KB)
- Portuguese - PT (418 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Cammalleri L, et al. Rasburicase represents a new tool for hyperuricemia in tumor lysis syndrome and in gout. Int J Med Sci. 2007 Mar 2;4(2):83-93. [Content Brief]
[2]. Xu H, et al. High-Dose IV Administration of Rasburicase Suppresses Anti-rasburicase Antibodies, Depletes Rasburicase-Specific Lymphocytes, and Upregulates Treg Cells. AAPS J. 2020 May 27;22(4):80. [Content Brief]
[3]. Kono H, et al. Uric acid promotes an acute inflammatory response to sterile cell death in mice. J Clin Invest. 2010 Jun;120(6):1939-49. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Rasburicase 関連分類
HY-108844 関連分類
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