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製品番号: HY-N10449

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Resistomycin

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Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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純度: 99.9%
CAS 番号: 20004-62-0
分子式: C₂₂H₁₆O₆
分子量:376.36

保管条件:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Resistomycin 構造式

CAS 番号: 20004-62-0

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製品説明

Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis^[1]^[2]^[3]^[4].

Antibiotic アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	0.5 μM Compound: 1	Antiproliferative activity against human CEM cells after 72 hrs by MTT assay Antiproliferative activity against human CEM cells after 72 hrs by MTT assay	[PMID: 29137865]
CCRF-CEM	IC₅₀	0.5 μM Compound: 5	Antiproliferative activity against human CEM cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human CEM cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 33974416]
HCT-116	IC₅₀	0.1 μM Compound: 1	Antiproliferative activity against p53 deficient human HCT116 cells after 72 hrs by MTT assay Antiproliferative activity against p53 deficient human HCT116 cells after 72 hrs by MTT assay	[PMID: 29137865]
HCT-116	IC₅₀	0.3 μM Compound: 1	Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 29137865]
HeLa	IC₅₀	0.1 μM Compound: 1	Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay	[PMID: 29137865]
HeLa	IC₅₀	0.1 μM Compound: 5	Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 33974416]
HMEC-1	IC₅₀	0.5 μM Compound: 1	Antiproliferative activity against HMEC1 cells after 72 hrs by MTT assay Antiproliferative activity against HMEC1 cells after 72 hrs by MTT assay	[PMID: 29137865]
HMEC-1	IC₅₀	0.5 μM Compound: 5	Cytotoxicity against human HMEC-1 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human HMEC-1 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 33974416]
K562	IC₅₀	0.3 μM Compound: 1	Antiproliferative activity against human K562 cells after 72 hrs by MTT assay Antiproliferative activity against human K562 cells after 72 hrs by MTT assay	[PMID: 29137865]
L1210	IC₅₀	0.7 μM Compound: 1	Antiproliferative activity against mouse L1210 cells after 72 hrs by MTT assay Antiproliferative activity against mouse L1210 cells after 72 hrs by MTT assay	[PMID: 29137865]
L1210	IC₅₀	0.7 μM Compound: 5	Antiproliferative activity against mouse L1210 cells assessed as growth inhibition after 72 hrs by MTT assay Antiproliferative activity against mouse L1210 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 33974416]
T-24	IC₅₀	26 μM Compound: 1	Growth inhibition of human T24 cells after 72 hrs by cell impedance method Growth inhibition of human T24 cells after 72 hrs by cell impedance method	[PMID: 29137865]

体外実験

Resistomycin attenuates triple-negative breast cancer progression by inhibiting E3 ligase Pellino-1 and inducing SNAIL/SLUG degradation^[1].
Resistomycin displays a high affinity for GST-Pellino-1 (K_D = 2.58 μM) as indicated by surface plasmon resonance^[1].
Resistomycin treatment reduced the expression of SNAIL and SLUG in TNBC cells^[1].
Resistomycin induced apoptosis and cycle arrest in human hepatocellular carcinoma cells by activating p38 MAPK pathway in vitro and in vivo^[3].