RIG 200
RIG 200 is an S-nitrosothiol nitric oxide (NO) donor. RIG 200 releases NO through decomposition, activating guanylate cyclase (sGCM) in vascular smooth muscle cells, increasing cGMP levels, and leading to vasodilation. RIG 200 significantly inhibits Collagen (HY-NP003)-induced platelet aggregation in platelet-rich plasma (PRP). RIG 200 may be used in research on antithrombus.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 202656-49-3
- 分子式: C21H31N3O12S
- 分子量:549.55
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
RIG 200 (4-100 μM) inhibits platelet aggregation induced by Collagen with an IC₅₀ of 0.8 μM in platelet-rich plasma (PRP) but is impossible to inhibit platelet aggregation in whole blood (WB)[1].
RIG 200 (10 μM) significantly increases the cGMP level of platelets in PRP[1].
RIG 200 (0.01-10 μM, 30 min) continuously inhibits the contraction effect of isolated vascular rings, and its dilating effect can significantly persist after elution[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 202656-49-3
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分子量 549.55
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分子式 C21H31N3O12S
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SMILES
CC(O[C@@H]1[C@H]([C@@H](O[C@H](COC(C)=O)[C@H]1OC(C)=O)OC(C)=O)NC([C@H](NC(C)=O)C(C)(C)SN=O)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Megson IL, et al. Inhibition of human platelet aggregation by a novel S-nitrosothiol is abolished by haemoglobin and red blood cells in vitro: implications for anti-thrombotic therapy. Br J Pharmacol. 2000 Dec;131(7):1391-8. [Content Brief]
[2]. Sogo N, et al. S-nitrosothiols cause prolonged, nitric oxide-mediated relaxation in human saphenous vein and internal mammary artery: therapeutic potential in bypass surgery. Br J Pharmacol. 2000 Nov;131(6):1236-44. [Content Brief]
[3]. Sogo N, et al. A novel S-nitrosothiol (RIG200) causes prolonged relaxation in dorsal hand veins with damaged endothelium. Clin Pharmacol Ther. 2000 Jul;68(1):75-81. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
RIG 200 関連分類
HY-107000 関連分類
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