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RNA binder 1

RNA binder 1 (Compound 4b) is a blood-brain permeable RNA binder. RNA binder 1 can selectively bind to the G-quadruplex structure of the G4C2 repeat sequence RNA of the C9orf72 gene. RNA binder 1 significantly reduces the levels of toxic polypeptides poly(GA) and poly(GP) produced by the G4C2 repeat sequence in amyotrophic lateral sclerosis (ALS) patient-derived cells. RNA binder 1 has no significant effect on the antisense polypeptide poly(PR), showing selectivity for sense RNA. RNA binder 1 can be used in the study of ALS and frontotemporal dementia (FTD).

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  • CAS 番号: 3105281-39-5
  • 分子式: C22H20N10S2
  • 分子量:488.59
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • RNA binder 1 Chemical Structure
    RNA binder 1 構造式
CAS 番号: 3105281-39-5
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  • RNA binder 1 Chemical Structure
    RNA binder 1 Chemical Structure
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  • RNA binder 1