RRD-251
Based on 1 Customer Validation
RRD-251 is an inhibitor of retinoblastoma tumor suppressor protein (Rb)-Raf-1 interaction, with potent anti-proliferative, anti-angiogenic and anti-tumor activities.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.87%
- CAS 番号: 72214-67-6
- 分子式: C8H9Cl3N2S
- 分子量:271.59
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Rb-Raf-1 interaction, apoptosis[1]
RRD-251 (10-50 μM; 24 hours) inhibits melanoma growth in-vitro[1].
RRD-251 (50 μM; 2 hours) inhibits Rb-Raf-1 interaction and Rb phosphorylation in non-small cell lung cancer cells[1].
RRD-251 induces apoptosis (50 μM; 18 hours) and cell cycle arrest (20-50 μM; 4 hours)[1].
RRD-251 alters the expression of cell cycle and apoptosis regulatory protein[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SK-MEL-28 cells , SK-MEL-5 cells, SK-MEL-2 cells
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Concentration:10 μM, 20 μM, 50 μM
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Incubation Time:24 hours
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Result:Inhibited melanoma growth in-vitro.
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Cell Line:SK-MEL-28 cells , SK-MEL-5 cells, SK-MEL-2 cells
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Concentration:50 μM
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Incubation Time:2 hours
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Result:Showed the depletion of phosphorylated-Rb in RRD-251 treated cells.
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Cell Line:SK-MEL-28 cells , SK-MEL-5 cells, SK-MEL-2 cells
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Concentration:50 μM
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Incubation Time:18 hours
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Result:Induced apoptosis.
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Cell Line:SK-MEL-28 cells , SK-MEL-5 cells
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Concentration:20 μM, 50 μM
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Incubation Time:4 hours
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Result:Resulted in a dose dependent inhibition of cell cycle progression in SK-MEL-28 and SK-MEL-5 cells, respectively.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:8-wk-old female athymic nude mice, with SK-ME-28 xenograft[1]
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Dosage:50 mg/kg
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Administration:Intraperitoneal administration, qod, for 14 days
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Result:Inhibits the growth of SK-ME-28 xenograft in nude mice.
化学情報
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CAS 番号 72214-67-6
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性状 Solid
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分子量 271.59
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分子式 C8H9Cl3N2S
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Color White to off-white
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SMILES
NC(SCC1=CC=C(Cl)C=C1Cl)=N.[H]Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : 125 mg/mL (460.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6820 mL | 18.4101 mL | 36.8202 mL | 92.0505 mL |
| 5 mM | 0.7364 mL | 3.6820 mL | 7.3640 mL | 18.4101 mL | |
| 10 mM | 0.3682 mL | 1.8410 mL | 3.6820 mL | 9.2051 mL | |
| 15 mM | 0.2455 mL | 1.2273 mL | 2.4547 mL | 6.1367 mL | |
| 20 mM | 0.1841 mL | 0.9205 mL | 1.8410 mL | 4.6025 mL | |
| 25 mM | 0.1473 mL | 0.7364 mL | 1.4728 mL | 3.6820 mL | |
| 30 mM | 0.1227 mL | 0.6137 mL | 1.2273 mL | 3.0684 mL | |
| 40 mM | 0.0921 mL | 0.4603 mL | 0.9205 mL | 2.3013 mL | |
| 50 mM | 0.0736 mL | 0.3682 mL | 0.7364 mL | 1.8410 mL | |
| 60 mM | 0.0614 mL | 0.3068 mL | 0.6137 mL | 1.5342 mL | |
| 80 mM | 0.0460 mL | 0.2301 mL | 0.4603 mL | 1.1506 mL | |
| 100 mM | 0.0368 mL | 0.1841 mL | 0.3682 mL | 0.9205 mL |
RRD-251 関連分類
HY-117737A 関連分類
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