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製品番号: HY-189280

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S-570

S-570 is an orally active selective STING antagonist. S-570 inhibits the secretion of the cytokines IFN-β and IL-6. S-570 can be used for research on inflammation.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2718206-92-7
分子式: C₁₇H₁₂ClF₃N₄
分子量:364.75

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

S-570 構造式

CAS 番号: 2718206-92-7

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
- Parmacokinetics
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
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生物活性

製品説明

S-570 is an orally active selective STING antagonist. S-570 inhibits the secretion of the cytokines IFN-β and IL-6. S-570 can be used for research on inflammation^[1].

IC₅₀ & Target

^[1]

IL-6

Interleukin Related アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC50	0.041 μM	Inhibition of human STING in human IRF-reporter HEK293 cells overexpressing human STING assessed as reduction in reporter activity by dose-response curve analysis. Inhibition of human STING in human IRF-reporter HEK293 cells overexpressing human STING assessed as reduction in reporter activity by dose-response curve analysis.	42562155
THP-1	IC50	0.018 μM	Inhibition of IFN-β secretion in 2′,3′-cGAMP-stimulated human monocyte THP-1 cells assessed by dose-response curve analysis. Inhibition of IFN-β secretion in 2′,3′-cGAMP-stimulated human monocyte THP-1 cells assessed by dose-response curve analysis.	42562155
B16	IC50	0.071 μM	Antagonist activity against mouse STING in CMA-stimulated mouse B16 cells assessed as reduction in reporter activity by dose-response curve analysis. Antagonist activity against mouse STING in CMA-stimulated mouse B16 cells assessed as reduction in reporter activity by dose-response curve analysis.	42562155

体外実験

S-570 is a potent hSTING antagonist in HEK293 cells with an IC₅₀ of 0.041 μM^[1].
S-570 potently inhibits IFN-β secretion in 2′,3′-cGAMP (HY-100564)-stimulated THP-1 cells with an IC₅₀ of 0.018 μM^[1].
S-570 (30 min) exhibits improved stability in liver microsomes, with 44.1% remaining after 30 min^[1].
S-570 is a potent mouse STING antagonist in mouse B16 cells with an IC₅₀ of 0.071 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	C₀	AUC_0-last	V_ss	CL	MRT_0-last	T_max	C_max	F
Mice^[1]	3 mg/kg	i.v.	0.616 h	8916 ng/mL	2081 ng·h/mL	0.442 L/kg	1.44 L/h/kg	0.301 h	/	/	/
Mice^[1]	30 mg/kg	p.o.	2.86 h	/	16054 ng·h/mL	/	/	1.647 h	1.00 h	7091 ng/mL	77.3 %

体内実験

S-570 (1-30 mg/kg; p.o.) effectively attenuates systemic inflammation in a CMA-stimulated mouse model by significantly suppressing IFN-β, IL-6, and TNF-α production in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice^[1]
Dosage:

1, 3, 10, 30 mg/kg
Administration:

p.o.
Result:

Suppressed plasma levels of IFN-β, IL-6, and TNF-α in a dose-dependent manner.

化学情報

CAS 番号 2718206-92-7
分子量 364.75
分子式 C₁₇H₁₂ClF₃N₄
SMILES

CN1C2=CC=C(C(F)(F)F)C=C2N=C1NC3=CNC4=C3C=C(Cl)C=C4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Kiyoi T, et al. Discovery of orally available benzimidazole-based STING antagonists with in vivo activity. Bioorganic & medicinal chemistry letters. 2026 Dec;141:130757.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

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S-570

Interleukin Related アイソフォーム固有の製品をすべて表示

生物活性