Salbostatin
Salbostatin is a competitive Trehalase inhibitor, with an IC50 of 8.3 μM against silkworm trehalase and a Ki of 180 nM against porcine trehalase. Salbostatin is isolated from Streptomyces albus. Salbostatin shows no antibacterial activity, and does not inhibit porcine intestinal mucosa sucrase (EC 3.2.1.26) or maltase (EC 3.2.1.20). Salbostatin can be used in studies related to the development of plant protectants.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 128826-89-1
- 分子式: C13H23NO8
- 分子量:321.32
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
[1]|
Microbial Metabolite |
体外実験
Salbostatin inhibits silkworm trehalase with an IC50 of 8.3 μM[1].
Salbostatin potently and competitively inhibits porcine kidney trehalase with a Ki = 180 nM, weakly inhibits murine liver aldose reductase, and does not inhibit porcine small intestine saccharase, maltase, or exhibit antibiotic activity[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
化学情報
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CAS 番号 128826-89-1
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分子量 321.32
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分子式 C13H23NO8
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SMILES
O[C@H]1[C@H](O)C(CO)=C[C@H](N[C@H]2CO[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H]1O
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Structure Classification
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Initial Source
Streptomyces albus
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
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Bacterial live/dead nucleic-acid viability staining
The LIVE/DEAD bacterial viability staining method is based on differential permeability of nucleic-acid-binding fluorescent dyes, most commonly SYTO 9 and propidium iodide (PI), which enables discrimination of bacterial populations with intact versus compromised cytoplasmic membranes. SYTO 9 penetrates both intact and damaged bacterial membranes and binds nucleic acids to produce green fluorescence, whereas propidium iodide penetrates only cells with compromised membranes and fluoresces red while also reducing SYTO 9 signal through competitive binding and fluorescence interactions. The resulting fluorescence pattern is interpreted as a proxy for membrane integrity, which is widely used as an indicator of bacterial viability in microscopy, flow cytometry, and spectroscopic platforms. However, mechanistic studies show that SYTO 9 and PI interactions involve displacement and fluorescence resonance energy transfer effects, which can influence signal interpretation depending on dye ratios a
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Salbostatin 関連分類
HY-N21814 関連分類
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