SB-258585
Based on 1 Customer Validation
SB-258585 is a selective ligand with high affinity for the 5-HT6 receptor, with a pKi value of 8.53.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.77%
- CAS 番号: 209480-63-7
- 分子式: C18H22IN3O3S
- 分子量:487.36
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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5-HT Receptor アイソフォーム固有の製品をすべて表示
More
生物活性
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5-HT6 Receptor |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Astrocyte | CC50 |
>1 μM
Compound: SB258585
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Toxicity in mouse C8-D1A astrocytes assessed as reduction in cell viability by MTT assay
Toxicity in mouse C8-D1A astrocytes assessed as reduction in cell viability by MTT assay
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[PMID: 33439019] |
| HeLa | IC50 |
0.019 μM
Compound: SB-258585
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Antagonist activity at human 5-HT6 receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation pretreated for 10 mins before 5-HT addition measured after 30 mins
Antagonist activity at human 5-HT6 receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation pretreated for 10 mins before 5-HT addition measured after 30 mins
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[PMID: 23820387] |
化学情報
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CAS 番号 209480-63-7
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性状 Solid
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分子量 487.36
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分子式 C18H22IN3O3S
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Color Light yellow to yellow
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SMILES
O=S(C1=CC=C(I)C=C1)(NC2=CC=C(OC)C(N3CCN(C)CC3)=C2)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 50 mg/mL (102.59 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0519 mL | 10.2594 mL | 20.5187 mL | 51.2968 mL |
| 5 mM | 0.4104 mL | 2.0519 mL | 4.1037 mL | 10.2594 mL | |
| 10 mM | 0.2052 mL | 1.0259 mL | 2.0519 mL | 5.1297 mL | |
| 15 mM | 0.1368 mL | 0.6840 mL | 1.3679 mL | 3.4198 mL | |
| 20 mM | 0.1026 mL | 0.5130 mL | 1.0259 mL | 2.5648 mL | |
| 25 mM | 0.0821 mL | 0.4104 mL | 0.8207 mL | 2.0519 mL | |
| 30 mM | 0.0684 mL | 0.3420 mL | 0.6840 mL | 1.7099 mL | |
| 40 mM | 0.0513 mL | 0.2565 mL | 0.5130 mL | 1.2824 mL | |
| 50 mM | 0.0410 mL | 0.2052 mL | 0.4104 mL | 1.0259 mL | |
| 60 mM | 0.0342 mL | 0.1710 mL | 0.3420 mL | 0.8549 mL | |
| 80 mM | 0.0256 mL | 0.1282 mL | 0.2565 mL | 0.6412 mL | |
| 100 mM | 0.0205 mL | 0.1026 mL | 0.2052 mL | 0.5130 mL |
SB-258585 関連分類
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