SB-587094
SB-587094 is a MetAP-2 inhibitor. SB-587094 inhibits cobalt- and manganese-containing hMetAP2. SB-587094 inhibits endothelial cell proliferation. SB-587094 is applicable to cancer-related research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 949142-44-3
- 分子式: C16H18N4S2
- 分子量:330.47
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HUVEC | IC50 |
150 nM
Compound: 102
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Growth inhibition of HUVEC cells by XTT assay
Growth inhibition of HUVEC cells by XTT assay
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[PMID: 17636946] |
SB-587094 (Thiophene 102) exhibits inhibitory activity against recombinant human cobalt-containing MetAP-2, with a Ki,app of 2 nM[2].
SB-587094 inhibits recombinant human manganese-containing MetAP-2 with an apparent inhibition constant (Ki,app) of 1500 nM[2].
SB-587094 (72 h) inhibits the proliferation of human umbilical vein endothelial cells with an IC50 of 150 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 949142-44-3
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分子量 330.47
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分子式 C16H18N4S2
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SMILES
CC(C)C1=C(C=CC=C1)NC2=NN=C(SCC3=CC=CS3)N2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Heinrich T, et al. Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors. J Med Chem. 2019;62(10):5025-5039. [Content Brief]
[2]. Marino JP Jr, et al. Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore. J Med Chem. 2007;50(16):3777-3785. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SB-587094 関連分類
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