製品番号: HY-108775

Sodium thiosulfate (98%)

(別名: Sodium hyposulfite (98%))

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Sodium thiosulfate (Sodium hyposulfite) is an antioxidant. Sodium thiosulfate inhibits the expression of p-GSK-3β and β-catenin proteins, reduces IL-1β, COX-2, and Iba-1, and inhibits NFκB activation. Sodium thiosulfate promotes angiogenesis, inhibits inflammation, and improves acute lung injury. Sodium thiosulfate also exhibits anti-cancer activity against melanoma. Sodium thiosulfate also exerts renal protective effects. Sodium thiosulfate can be used in the research of osteoarthritis, brain inflammation, cancer (such as breast cancer, melanoma), and kidney disease.

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純度: 98.30%
CAS 番号: 7772-98-7
分子式: Na₂S₂O₃
分子量:158.11

保管条件:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

Sodium thiosulfate (98%) 構造式

CAS 番号: 7772-98-7

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

COX アイソフォーム固有の製品をすべて表示 :

NF-κB アイソフォーム固有の製品をすべて表示 :

Interleukin Related アイソフォーム固有の製品をすべて表示 :

GSK-3 アイソフォーム固有の製品をすべて表示 :

体外実験

Sodium thiosulfate (1.2-120 μM; 48 h) does not affect MCF-7 viability^[1].
Sodium thiosulfate (3 mM; 8 h) stimulates proliferation of human umbilical vein endothelial cells (HUVEC)^[2].
Sodium thiosulfate (0.2-25 mM; 1-7 days) dose-dependently inhibits mineralization of murine joint chondrocytes^[3].
Sodium thiosulfate (1-500 μM; 8 h) reduces LPS/IFNγ-induced release of TNFα and IL-6 in microglia^[4].
Sodium thiosulfate (0.1-10 mM; 48 h) does not attenuate the anticancer activity of Doxorubicin (HY-15142A) in human breast cancer MCF-7 cells and human cervical cancer HeLa cells^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Sodium thiosulfate (0.5-1 g/kg/day; p.o. via water bottle; changed three times a week) promotes hindlimb ischemia-induced revascularization and muscle recovery in WT C57BL/6JRj mice and hypercholesterolemic LDLR^-/- mice, increases capillary density, reduces muscle damage^[2].
Sodium thiosulfate (0.4 g/kg; i.p.; three times per week) reduces the volume and crystal content of new periarticular calcific deposits, attenuates tibial and femoral cartilage damage and proteoglycan loss, and shows a significant positive correlation between the volume of new mineralized structures and tibial cartilage degradation score in menisectomy-induced osteoarthritis model of female C57BL/6 mice^[3].
Sodium thiosulfate (2 g/kg; intraperitoneal injection, 0 and 12 h after LPS challenge; 0.5 g/kg; i.v., 10 min after CLP) attenuates LPS or CLP-induced acute lung injury in male C57BL6J mice by inhibiting lung inflammation, reducing lung permeability, and suppressing NFκB activation^[5].
Sodium thiosulfate (2-3 g/kg; once daily) inhibits tumor growth and EMT process by the Wnt/β-catenin signaling pathway in nude mice xenografted with B16 cells^[8].
Sodium thiosulfate (100-750 mg/kg; i.p.) reduces brain inflammation induced by systemic lipopolysaccharide administration in female C57BL/6J mice by decreasing IL-1β, COX-2, Iba-1, and TSPO levels ^[9].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 7772-98-7
性状 Solid
分子量 158.11
分子式 Na₂S₂O₃
Color White to off-white
SMILES

[Na][Na].O=S(=O)=S=O
別名

Sodium hyposulfite (98%)
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

溶剤 & 溶解度

体外:

H₂O : ≥ 100 mg/mL (632.47 mM)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.3247 mL

31.6236 mL

63.2471 mL

5 mM

1.2649 mL

6.3247 mL

12.6494 mL

10 mM

0.6325 mL

3.1624 mL

6.3247 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (279 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Ota A, et al. The selective cytotoxicity of silver thiosulfate, a silver complex, on MCF-7 breast cancer cells through ROS-induced cell death. Pharmacol Rep. 2021 Jun;73(3):847-857. [Content Brief]

[2]. Macabrey D, et al. Sodium thiosulfate, a source of hydrogen sulfide, stimulates endothelial cell proliferation and neovascularization. Front Cardiovasc Med. 2022 Oct 3;9:965965. [Content Brief]

[3]. Nasi S, et al. Sodium Thiosulfate Prevents Chondrocyte Mineralization and Reduces the Severity of Murine Osteoarthritis. PLoS One. 2016 Jul 8;11(7):e0158196. [Content Brief]

[4]. Lee M, et al. Sodium thiosulfate attenuates glial-mediated neuroinflammation in degenerative neurological diseases. J Neuroinflammation. 2016 Feb 8;13:32. [Content Brief]

[5]. Sakaguchi M, et al. Sodium thiosulfate attenuates acute lung injury in mice. Anesthesiology. 2014 Dec;121(6):1248-57. [Content Brief]

[6]. Mizuta Y, et al. Sodium thiosulfate prevents doxorubicin-induced DNA damage and apoptosis in cardiomyocytes in mice. Life Sci. 2020 Sep 15;257:118074. [Content Brief]

[7]. Bijarnia RK, et al. Sodium thiosulfate ameliorates oxidative stress and preserves renal function in hyperoxaluric rats. PLoS One. 2015 Apr 30;10(4):e0124881. [Content Brief]

[8]. Wang D, et al. Sodium thiosulfate inhibits epithelial-mesenchymal transition in melanoma via regulating the Wnt/β-catenin signaling pathway. J Dermatol Sci. 2023 Feb;109(2):89-98. [Content Brief]

[9]. Acero G, et al. Sodium thiosulphate attenuates brain inflammation induced by systemic lipopolysaccharide administration in C57BL/6J mice. Inflammopharmacology. 2017 May 19. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	6.3247 mL	31.6236 mL	63.2471 mL	158.1178 mL
	5 mM	1.2649 mL	6.3247 mL	12.6494 mL	31.6236 mL
	10 mM	0.6325 mL	3.1624 mL	6.3247 mL	15.8118 mL
	15 mM	0.4216 mL	2.1082 mL	4.2165 mL	10.5412 mL
	20 mM	0.3162 mL	1.5812 mL	3.1624 mL	7.9059 mL
	25 mM	0.2530 mL	1.2649 mL	2.5299 mL	6.3247 mL
	30 mM	0.2108 mL	1.0541 mL	2.1082 mL	5.2706 mL
	40 mM	0.1581 mL	0.7906 mL	1.5812 mL	3.9529 mL
	50 mM	0.1265 mL	0.6325 mL	1.2649 mL	3.1624 mL
	60 mM	0.1054 mL	0.5271 mL	1.0541 mL	2.6353 mL
	80 mM	0.0791 mL	0.3953 mL	0.7906 mL	1.9765 mL
	100 mM	0.0632 mL	0.3162 mL	0.6325 mL	1.5812 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sodium thiosulfate (98%)

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COX アイソフォーム固有の製品をすべて表示

NF-κB アイソフォーム固有の製品をすべて表示

Interleukin Related アイソフォーム固有の製品をすべて表示

GSK-3 アイソフォーム固有の製品をすべて表示

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table