SP-471P
Based on 1 Customer Validation
SP-471P is a potent dengue virus (DENV) protease inhibitor with EC50s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM for DENV1, DENV2, DENV3 and DENV4, respectively and CC50 value over 100 μM. SP-471P can reduce DENV viral RNA synthesis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.46%
- CAS 番号: 2768011-36-3
- 分子式: C33H26BrN5O2
- 分子量:604.50
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保管条件:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示
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生物活性
EC50: 5.9 μM (DENV1), 1.4 μM (DENV2), 5.1 μM (DENV3), 1.7 μM (DENV4)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
>100 μM
Compound: 32a; SP-471P
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Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability
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[PMID: 34298282] |
| PBMC | CC50 |
>100 μM
Compound: 32a; SP-471P
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Cytotoxicity against human PBMC assessed as reduction in cell viability
Cytotoxicity against human PBMC assessed as reduction in cell viability
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[PMID: 34298282] |
SP-471P (0-10 μM) shows low micromolar efficacy for DENV1, DENV2, DENV3 and DENV4 with EC50s of 5.9 μM, 1.4 μM, 5.1 μM and 1.7 μM, respectively[1].
SP-471P (10 μM; 48 hours) exhibits an EC50 value of 1.5 μM for ADE infection in human peripheral blood mononuclear cells[1].
SP-471P (10 μM; 6-54 hours) reduces viral RNA synthesis of DENV2[1].
SP-471P (10 μM; 30 hours) targets the NS3int cleavage site of DENV in DENV2-infected Huh7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human peripheral blood mononuclear cells (infected with ADE)[1]
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Concentration:10 μM
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Incubation Time:48 hours
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Result:Resulted in an EC50 value of 1.5 μM for ADE infection in human PBMCs.
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Cell Line:Huh7 (infected with DENV2 at MOI 1 for 6 hours)[1]
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Concentration:10 μM
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Incubation Time:6-54 hours
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Result:Reduced viral RNA synthesis.
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Cell Line:Huh7 (infected with DENV2 at MOI 1 for 6 hours)[1]
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Concentration:10 μM
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Incubation Time:30 hours
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Result:Targeted the NS3int cleavage site of DENV.
化学情報
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CAS 番号 2768011-36-3
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性状 Solid
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分子量 604.50
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分子式 C33H26BrN5O2
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Color White to off-white
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SMILES
N/C(C1=CC=CC(C2=CC=C3C(C4=C(N3CC5=CC=CC(Br)=C5)C=CC(C6=CC=CC(/C(N)=N/O)=C6)=C4)=C2)=C1)=N\O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
純度とドキュメンテーション
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データシート (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SP-471P 関連分類
HY-144645 関連分類
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