Spectramide
Spectramide is a blood-brain barrier-permeable, reversible, and selective dopamine D2 receptor ligand. Spectramide shows no strong interactions with dopamine D1 receptors, dopamine uptake sites, adrenergic receptor systems, cholinergic receptor systems, or 5-HTR systems. Spectramide can be labeled with 11C or 123I isotopes for use in PET or SPECT. Spectramide preferentially accumulates in the striatum with low uptake in other brain regions, and its accumulation can be blocked by pre-administration of Haloperidol (HY-14538).
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- CAS 番号: 125141-02-8
- 分子式: C19H23ClIN3O2
- 分子量:487.76
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Dopamine Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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D2 Receptor |
125I-Spectramide (increasing concentrations; 30 minutes) binds to a single population of high-affinity dopamine D2 receptors in rat striatal homogenates with a Kd of 25 pM and a Bmax of 20 pmol/g tissue[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 125141-02-8
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分子量 487.76
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分子式 C19H23ClIN3O2
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SMILES
O=C(C1=CC(Cl)=C(NC)C=C1OC)NCCN(CC2=CC=C(C=C2)I)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Spectramide 関連分類
HY-183927 関連分類
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