SR-4133
SR-4133 is a potent and highly CK1ε selective inhibitor with an IC50 of 58 nM. SR-4133 binds to the ATP-binding site of CK1ε. SR-4133 displays nanomolar growth inhibition of bladder cancer cells, and inhibits the phosphorylation of 4E-BP1.
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- CAS 番号: 2999645-23-5
- 分子式: C27H22F2N8O
- 分子量:512.51
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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CK1ε 58 nM (IC50) |
CK1γ2 10 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 5637 | EC50 |
314 nM
Compound: SR-4133
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Antiproliferative activity against human 5637 cells assessed as reduction in cell proliferation incubated for 72 hrs by Cell Titer Glo assay
Antiproliferative activity against human 5637 cells assessed as reduction in cell proliferation incubated for 72 hrs by Cell Titer Glo assay
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[PMID: 37204207] |
| T-24 | EC50 |
265 nM
Compound: SR-4133
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Antiproliferative activity against human T24 cells assessed as reduction in cell proliferation incubated for 72 hrs by Cell Titer Glo assay
Antiproliferative activity against human T24 cells assessed as reduction in cell proliferation incubated for 72 hrs by Cell Titer Glo assay
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[PMID: 37204207] |
| U2OS | EC50 |
373 nM
Compound: SR-4133
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Antiproliferative activity against human U2OS cells assessed as reduction in cell proliferation incubated for 72 hrs by Cell Titer Glo assay
Antiproliferative activity against human U2OS cells assessed as reduction in cell proliferation incubated for 72 hrs by Cell Titer Glo assay
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[PMID: 37204207] |
| UMUC3 | EC50 |
540 nM
Compound: SR-4133
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Antiproliferative activity against human UMUC3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Cell Titer Glo assay
Antiproliferative activity against human UMUC3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Cell Titer Glo assay
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[PMID: 37204207] |
SR-4133 (200-600 nM, 72 h) inhibits cancer cells growth significantly with EC50s of 265 nM (T24), 314 nM (5637), 540 nM (UM-UC-3 EC), 373 nM (U2-OS EC)[1].
SR-4133 (1 μM, 24 h) inhibits the phosphorylation of 4E-BP1 in T24 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:T24, 5637, UM-UC-3, U2-OS
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Concentration:265 nM, 314 nM, 540 nM, 373 nM
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Incubation Time:72 h
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Result:Inhibited cell growth with EC50s of 265 nM (T24), 314 nM (5637), 540 nM (UM-UC-3 EC), 373 nM (U2-OS EC).
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Cell Line:T24
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Concentration:1 μM
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Incubation Time:24 h
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Result:Blocked the phosphorylation of T37/46, S65, and T70 of 4E-BP1.
化学情報
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CAS 番号 2999645-23-5
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分子量 512.51
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分子式 C27H22F2N8O
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SMILES
FC1=C(F)C2=C(NC(CNC3=NC(N4CCOCC4)=NC5=C3N=CN5C6=CC(C=CC=C7)=C7C=C6)=N2)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SR-4133 関連分類
HY-149292 関連分類
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