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製品番号: HY-184822

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STAT6-IN-14

STAT6-IN-14 is a STAT6 inhibitor that blocks the binding of STAT6-pIL-4Rα, with an IC₅₀ of 1.20 μM. STAT6-IN-14 can inhibit IL-4-induced STAT6 transcriptional activity in STAT6-HEK293 cells. STAT6-IN-14 can be used for research on allergic diseases and inflammation.

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CAS 番号: 3033741-74-8
分子式: C₂₉H₂₄F₄N₆O₃
分子量:580.53

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

STAT6-IN-14 構造式

CAS 番号: 3033741-74-8

容量

価格（税別）

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数量

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

STAT6

1.2 μM (IC₅₀)

STAT アイソフォーム固有の製品をすべて表示 :

体外実験

STAT6-IN-14 (Compound 39) inhibits the binding of human STAT6 to phosphorylated IL-4 receptor α (pIL-4Rα) in a cell‑free system, with an IC₅₀of 1.20 μM (30 min pre‑incubation + 30 min fluorescence polarization detection)^[1].
STAT6-IN-14 (0.1-1 μM; 1 h pre‑incubation + 6 h IL‑4 stimulation) inhibits STAT6‑mediated transcriptional activity in HEK293 cells overexpressing human STAT6, with inhibition rates of 99% at 1 μM and 84% at 0.1 μM, and no significant cytotoxicity is observed^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HEK293 cells
Concentration:

0.1 μM
Incubation Time:

1 h pre‑incubation + 6 h IL‑4 stimulation
Result:

Inhibited STAT6-mediated transcriptional activity with an inhibition rate of 84%, and the cell viability was > 70%, indicating no significant cytotoxicity at this concentration.

化学情報

CAS 番号 3033741-74-8
分子量 580.53
分子式 C₂₉H₂₄F₄N₆O₃
SMILES

O=C(C1=CC(NC(C2=CC(C(F)(F)F)=CC3=C2N(CC)C(C4=CC=C(N5C(N(C)N=C5C)=O)C=C4)=C3)=O)=CC=C1F)N
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Sumikawa, Y., et al. "Fused Ring Compound and Pharmaceutical Containing the Same." World Intellectual Property Organization, 4 Apr. 2024, WO 2024/071439 A1.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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STAT6-IN-14

STAT アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

STAT6-IN-14 関連分類

HY-184822 関連分類