Sulfiram
Based on 1 Customer Validation
Sulfiram is a very weak aldehyde dehydrogenase (ALDH) inhibitor, with an IC50 value of 413 μM against Saccharomyces cerevisiae ALDH. As a photochemical precursor, Sulfiram undergoes photoconversion to form Disulfiram (HY-B0240), a potent ALDH inhibitor. Sulfiram inhibits the dimerization of the extracellular domain fragment (amino acid residues 230-624) of amyloid precursor protein (APP), alters the monomer-dimer equilibrium, induces conformational changes in the fragment, and enhances the production of sAPPα via α-cleavage of APP. Sulfiram can be used in research related to scabies and Alzheimer's disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 96.35%
- CAS 番号: 95-05-6
- 分子式: C10H20N2S3
- 分子量:264.47
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保管条件:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Sulfiram is a very weak inhibitor of mitochondrial ALDH in Saccharomyces cerevisiae, but undergoes phototransformation to form the potent ALDH inhibitor Disulfiram under indoor light or 350 nm irradiation, resulting in a time-dependent increase in ALDH inhibitory activity[1].
Sulfiram (1 μM; 24 h) enhances α-cleavage of APP and reduces its β-cleavage, increasing the α/β cleavage ratio in 7W-CHO cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 95-05-6
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性状 Viscous Liquid
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分子量 264.47
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分子式 C10H20N2S3
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Color Light yellow to yellow
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SMILES
S=C(N(CC)CC)SC(N(CC)CC)=S
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (378.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (270 KB)
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SDS (393 KB)
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- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Mays DC, et al. Photolysis of sulfiram: a mechanism for its disulfiram-like reaction. Biochem Pharmacol. 1994;48(10):1917-1925. [Content Brief]
[2]. Libeu CA, et al. Altering APP proteolysis: increasing sAPPalpha production by targeting dimerization of the APP ectodomain. PLoS One. 2012;7(6):e40027. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7811 mL | 18.9057 mL | 37.8115 mL | 94.5287 mL |
| 5 mM | 0.7562 mL | 3.7811 mL | 7.5623 mL | 18.9057 mL | |
| 10 mM | 0.3781 mL | 1.8906 mL | 3.7811 mL | 9.4529 mL | |
| 15 mM | 0.2521 mL | 1.2604 mL | 2.5208 mL | 6.3019 mL | |
| 20 mM | 0.1891 mL | 0.9453 mL | 1.8906 mL | 4.7264 mL | |
| 25 mM | 0.1512 mL | 0.7562 mL | 1.5125 mL | 3.7811 mL | |
| 30 mM | 0.1260 mL | 0.6302 mL | 1.2604 mL | 3.1510 mL | |
| 40 mM | 0.0945 mL | 0.4726 mL | 0.9453 mL | 2.3632 mL | |
| 50 mM | 0.0756 mL | 0.3781 mL | 0.7562 mL | 1.8906 mL | |
| 60 mM | 0.0630 mL | 0.3151 mL | 0.6302 mL | 1.5755 mL | |
| 80 mM | 0.0473 mL | 0.2363 mL | 0.4726 mL | 1.1816 mL | |
| 100 mM | 0.0378 mL | 0.1891 mL | 0.3781 mL | 0.9453 mL |
Sulfiram 関連分類
HY-121817 関連分類
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