TN-101
TN-101 is an orally active NLRP3 inhibitor (IC50 = 29.8 nM). TN-101 can be used for the study of obesity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C18H20FIN2O3
- 分子量:458.27
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
-
Help & FAQs
生物活性
|
NLRP3 29.8 nM (IC50) |
TN-101 (2 h) can effectively inhibit the secretion of IL-1β (IC50 = 5.58 nM) by THP-1 cells, under Lipopolysaccharides (HY-D1056) (LPS)/Nigericin (HY-127019) stimulation[1].
TN-101 (0.3 nM-6 μM, 1 h) can dose-dependently inhibit the secretion of IL-1β (IC50 = 5.97 nM) and IL-18 (IC50 = 12.2 nM) in THP-1 cells induced by Palmitic acid (HY-N0830)-BSA complex[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Diet-induced obese (DIO) and Normal chow (NC)-fed lean mice[1].
-
Dosage:1 mg/kg, 3 mg/kg, 10 mg/kg
-
Administration:P.o., twice daily for 15 days
-
Result:Showed no effect on the weight of DIO and NC lean mice.
-
Animal Model:Diet-induced obese (DIO) and Normal chow (NC)-fed lean mice[1].
-
Dosage:1 mg/kg
-
Administration:P.o., twice daily for 28 days
-
Result:Showed no effect on the weight of DIO and NC lean mice.
化学情報
-
分子量 458.27
-
分子式 C18H20FIN2O3
-
SMILES
O[C@]1(C[C@H](C1)NC(CN2C[C@@]3(C4=C(C2=O)C=CC(I)=C4)C[C@H]3F)=O)C
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
TN-101 関連分類
HY-179132 関連分類
Powered by Bioz