TNIK-IN-9
TNIK-IN-9 (Compound 54) is a selective and potent NIK inhibitor, with an IC50 of 1.27 nM. TNIK-IN-9 can inhibit pro-inflammatory cytokines and nitric oxide production. TNIK-IN-9 exhibits significant anti-inflammatory effects, improved mortality, and hepatoprotective effects in sepsis models.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3038178-73-0
- 分子式: C24H21N7O3S
- 分子量:487.53
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
Pharmacokinetic Analysis in C57BL/6J Mouse Model[1]
| Route | Dose (mg/kg) | AUClast (ng·h/mL) | AUCinf (ng·h/mL) | T1/2 (h) | C0 (ng/mL) | CL (mL/min/kg) | Cmax (ng/mL) | Tmax(h) |
| i.v. | 10 | 3019 | 3021 | 0.741 | 5059 | 56.2 | / | / |
| i.p. | 10 | 2525 | 2551 | 2.27 | / | / | 1280 | 0.50 |