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製品番号: HY-10893

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TNK-651

TNK-651 is a non-nucleoside HIV-1 reverse transcriptase inhibitor. TNK-651 exhibits inhibitory effects on both the HIV-1 SF33 strain and the NNRTI-resistant HIV-1 A17 strain. TNK-651 can be used for the study of HIV-1 infection.

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CAS 番号: 175739-42-1
分子式: C₂₂H₂₄N₂O₃
分子量:364.44

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

TNK-651 構造式

CAS 番号: 175739-42-1

容量

価格（税別）

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数量

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

HIV アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
CEM-SS	CC₅₀	>20 μM Compound: 3, TNK-651	Cytotoxicity in human CEM-SS cells after 6 days by MTS assay Cytotoxicity in human CEM-SS cells after 6 days by MTS assay	[PMID: 21499541]
CEM-SS	EC₅₀	0.013 μM Compound: 3, TNK-651	Antiviral activity against HIV1 3B infected in human CEM-SS cells assessed as inhibition of viral replication after 6 days by MTS assay Antiviral activity against HIV1 3B infected in human CEM-SS cells assessed as inhibition of viral replication after 6 days by MTS assay	[PMID: 21499541]
MT4	CC₅₀	84.596 μM Compound: 2, TNK-651	Cytotoxicity against human MT4 cells after 3 days by XTT assay Cytotoxicity against human MT4 cells after 3 days by XTT assay	[PMID: 23540737]
MT4	CC₅₀	84.6 μM Compound: 18, TNK-651	Cytotoxicity against human MT4 cells after 3 days by XTT assay Cytotoxicity against human MT4 cells after 3 days by XTT assay	[PMID: 22283377]
MT4	EC₅₀	>10 μM Compound: 18, TNK-651	Antiviral activity against NNRTI-resistant HIV1 A17 expressing reverse transcriptase K103N and Y181C mutant infected in human MT4 cells assessed as inhibition of viral p24 antigen production after 7 days by ELISA Antiviral activity against NNRTI-resistant HIV1 A17 expressing reverse transcriptase K103N and Y181C mutant infected in human MT4 cells assessed as inhibition of viral p24 antigen production after 7 days by ELISA	[PMID: 22283377]
MT4	EC₅₀	>10 μM Compound: 2, TNK-651	Antiviral activity against NNRTI-resistant Human immunodeficiency virus 1 A17 double mutant infected in human MT4 cells assessed decrease in p24 level after 7 days by ELISA Antiviral activity against NNRTI-resistant Human immunodeficiency virus 1 A17 double mutant infected in human MT4 cells assessed decrease in p24 level after 7 days by ELISA	[PMID: 23540737]
MT4	EC₅₀	>10 μM Compound: 2, TNK-651	Antiviral activity against NNRTI-resistant Human immunodeficiency virus 1 harboring reverse transcriptase Y181C mutation infected in human MT4 cells assessed decrease in p24 level after 7 days by ELISA Antiviral activity against NNRTI-resistant Human immunodeficiency virus 1 harboring reverse transcriptase Y181C mutation infected in human MT4 cells assessed decrease in p24 level after 7 days by ELISA	[PMID: 23540737]
MT4	EC₅₀	0.022 μM Compound: 18, TNK-651	Antiviral activity against HIV1 SF33 infected in human MT4 cells assessed as inhibition of viral p24 antigen production after 7 days by ELISA Antiviral activity against HIV1 SF33 infected in human MT4 cells assessed as inhibition of viral p24 antigen production after 7 days by ELISA	[PMID: 22283377]
MT4	EC₅₀	0.022 μM Compound: 2, TNK-651	Antiviral activity against Human immunodeficiency virus 1 SF33 infected in human MT4 cells assessed decrease in p24 level after 7 days by ELISA Antiviral activity against Human immunodeficiency virus 1 SF33 infected in human MT4 cells assessed decrease in p24 level after 7 days by ELISA	[PMID: 23540737]
MT4	EC₅₀	2.398 μM Compound: 2, TNK-651	Antiviral activity against NNRTI-resistant Human immunodeficiency virus 1 harboring reverse transcriptase K103N mutation infected in human MT4 cells assessed decrease in p24 level after 7 days by ELISA Antiviral activity against NNRTI-resistant Human immunodeficiency virus 1 harboring reverse transcriptase K103N mutation infected in human MT4 cells assessed decrease in p24 level after 7 days by ELISA	[PMID: 23540737]
PBMC	CC₅₀	>10 μM Compound: 4b, ZW-IV-55-1, TNK651	Cytotoxicity against human PBMC Cytotoxicity against human PBMC	[PMID: 17608468]
TZM	CC₅₀	65.812 μM Compound: 2, TNK-651	Cytotoxicity against human TZM-bl cells Cytotoxicity against human TZM-bl cells	[PMID: 23540737]

化学情報

CAS 番号 175739-42-1
分子量 364.44
分子式 C₂₂H₂₄N₂O₃
SMILES

O=C1C(C(C)C)=C(CC2=CC=CC=C2)N(COCC3=CC=CC=C3)C(N1)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wang X, et al. Design, synthesis, and biological evaluation of 1-[(2-benzyloxyl/alkoxyl)methyl]-5-halo-6-aryluracils as potent HIV-1 non-nucleoside reverse transcriptase inhibitors with an improved drug resistance profile. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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TNK-651

HIV アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

TNK-651 関連分類

HY-10893 関連分類