USP10-IN-3
Based on 1 Customer Validation
USP10-IN-3 (compound D1) is a potent USP10 inhibitor with an IC50 value of 7.2 µM. USP10-IN-3 inhibits cell proliferation. USP10-IN-3 induces apoptosis and cell cycle arrest at S-phase.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.00%
- CAS 番号: 3059565-11-3
- 分子式: C29H25ClN4O3
- 分子量:512.99
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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USP10 7.2 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| Bel-7402 | IC50 |
2.3 μM
Compound: D1
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Antiproliferative activity against human Bel-7402 cells by CCK-8 method
Antiproliferative activity against human Bel-7402 cells by CCK-8 method
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[PMID: 38718626] |
USP10-IN-3 (compound D1) (0-100 µM) inhibits cell proliferation with an IC50 value of 2.3 µM for Huh-7 cells[1].
USP10-IN-3 (compound D1) (0-10 µM; 24 h) induces apoptosis and cell cycle arrest at S-phase in a dose-dependent manner[1].
USP10-IN-3 (compound D1) (0-30 µM; 24 h) decreases the expression of YAP1, p53, p21 in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Huh-7 cells
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Concentration:0, 0.625, 1.25, 2.5, 5, 10 µM
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Incubation Time:24 h
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Result:Induced apoptosis in a dose-dependent manner.
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Cell Line:Huh-7 cells
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Concentration:0, 0.625, 1.25, 2.5, 5 µM
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Incubation Time:24 h
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Result:Induced cell cycle arrest at S-phase.
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Cell Line:Huh-7 cells
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Concentration:0, 0.37, 1.1, 3.3, 10, 30 µM
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Incubation Time:24 h
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Result:Decreased the expression of YAP1, p53, p21 in a dose-dependent manner.
化学情報
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CAS 番号 3059565-11-3
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性状 Solid
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分子量 512.99
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分子式 C29H25ClN4O3
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Color White to off-white
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SMILES
CC1=CC=C2C(C(C3=NC(C4=C(C=CC=C4)C)=NO3)=CN(C2=C1)CC(NCCC5=CC=C(C=C5)Cl)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 5 mg/mL (9.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (278 KB)
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SDS (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9494 mL | 9.7468 mL | 19.4936 mL | 48.7339 mL |
| 5 mM | 0.3899 mL | 1.9494 mL | 3.8987 mL | 9.7468 mL |
USP10-IN-3 関連分類
HY-163622 関連分類
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