Volvaltrate B
Volvaltrate B is an anticancer agent, iridoid, can be obtained from the root of valerian (Valeriana officinalis). Volvaltrate B is effective against ovarian tumors in female mice. Volvaltrate B has the potential to study cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1181224-13-4
- 分子式: C27H41ClO11
- 分子量:577.06
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
製品説明
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
8.5 μM
Compound: 6
|
Cytotoxicity against human A549 cells after 24 hrs by MTT assay
Cytotoxicity against human A549 cells after 24 hrs by MTT assay
|
[PMID: 20853876] |
| Bel-7402 | IC50 |
6.1 μM
Compound: 6
|
Cytotoxicity against human Bel7402 cells after 24 hrs by MTT assay
Cytotoxicity against human Bel7402 cells after 24 hrs by MTT assay
|
[PMID: 20853876] |
| HCT-8 | IC50 |
3.2 μM
Compound: 6
|
Cytotoxicity against human HCT8 cells after 24 hrs by MTT assay
Cytotoxicity against human HCT8 cells after 24 hrs by MTT assay
|
[PMID: 20853876] |
| PC-3M | IC50 |
2 μM
Compound: 6
|
Cytotoxicity against human PC3M cells after 24 hrs by MTT assay
Cytotoxicity against human PC3M cells after 24 hrs by MTT assay
|
[PMID: 20853876] |
化学情報
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CAS 番号 1181224-13-4
-
分子量 577.06
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分子式 C27H41ClO11
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SMILES
CC(C)[C@@H](OC(CC(C)C)=O)C(OCC1=CO[C@@H](OC(CC(C)C)=O)[C@@]2([H])[C@]1(O)C[C@H](OC(C)=O)[C@@]2(CCl)O)=O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Tan YZ, et al. Iridoids from Valeriana jatamansi induce autophagy-associated cell death via the PDK1/Akt/mTOR pathway in HCT116 human colorectal carcinoma cells. Bioorg Chem. 2019 Jun;87:136-141. [Content Brief]
[2]. Wang PC, et al. Iridoids and sesquiterpenoids from the roots of Valeriana officinalis. J Nat Prod. 2009 Sep;72(9):1682-5. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)