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製品番号: HY-119161

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VX-759

Name: VX-759
Brand: MedChemExpress
SKU: HY-119161
Availability: PreOrder

(別名: VCH-759)

VX-759 (VCH-759) is an orally active HCV NS5B RNA-dependent RNA polymerase inhibitor. VX-759 is promising for research of chronic hepatitis C.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 478025-29-5
分子式: C₂₂H₂₇NO₃S
分子量:385.52

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

VX-759 構造式

CAS 番号: 478025-29-5

容量

価格（税別）

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数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 臨床実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

VX-759 (VCH-759) is an orally active HCV NS5B RNA-dependent RNA polymerase inhibitor. VX-759 is promising for research of chronic hepatitis C^[1].

IC₅₀ & Target

RNA Polymerase

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	>50000 nM Compound: 21	Cytotoxicity against human HuH7 cells by MTT assay Cytotoxicity against human HuH7 cells by MTT assay	[PMID: 19877603]
Huh-7	CC₅₀	>=20 μM Compound: 9	Cytotoxicity against human HuH7 cells after 3 days by Cell Titre Glo assay Cytotoxicity against human HuH7 cells after 3 days by Cell Titre Glo assay	[PMID: 24144213]
Huh-7	CC₅₀	48 μM Compound: 2	Cytotoxicity against human HuH7 cells by WST-1 assay Cytotoxicity against human HuH7 cells by WST-1 assay	[PMID: 20584604]
Huh-7	EC₅₀	0.23 μM Compound: 2	Antiviral activity against HSV Con1 GT1b infected in HuH7 cells by replicon assay Antiviral activity against HSV Con1 GT1b infected in HuH7 cells by replicon assay	[PMID: 20584604]
Huh-7	EC₅₀	1400 nM Compound: 21	Antiviral activity against HCV1b Con1 infected in human Huh7 clone HBI10A cells expressing HEPREP 1b replicon by cell-ELISA assay Antiviral activity against HCV1b Con1 infected in human Huh7 clone HBI10A cells expressing HEPREP 1b replicon by cell-ELISA assay	[PMID: 19877603]
Huh-7	EC₅₀	170 nM Compound: 9	Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as intrinsic antiviral potency after 72 hrs by luciferase reporter gene assay Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as intrinsic antiviral potency after 72 hrs by luciferase reporter gene assay	[PMID: 24144213]
Huh-7	EC₅₀	2100 nM Compound: 9	Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as observed antiviral potency after 72 hrs by luciferase reporter gene assay Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as observed antiviral potency after 72 hrs by luciferase reporter gene assay	[PMID: 24144213]
Huh-7	EC₅₀	593 nM Compound: 9	Antiviral activity against Hepatitis C virus Con1 genotype 1b infected in human HuH7 cells after 72 hrs by luciferase reporter gene assay Antiviral activity against Hepatitis C virus Con1 genotype 1b infected in human HuH7 cells after 72 hrs by luciferase reporter gene assay	[PMID: 24144213]
MT4	CC₅₀	>20 μM Compound: 9	Cytotoxicity against human MT4 cells after 5 days by Cell Titre Glo assay Cytotoxicity against human MT4 cells after 5 days by Cell Titre Glo assay	[PMID: 24144213]

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 478025-29-5
分子量 385.52
分子式 C₂₂H₂₇NO₃S
SMILES

O=C([C@@H]1CC[C@H](CC1)C)N(C2=C(SC(C3=CC=CC=C3)=C2)C(O)=O)C(C)C
別名

VCH-759
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Cooper C, et al. Evaluation of VCH-759 monotherapy in hepatitis C infection. J Hepatol. 2009 Jul;51(1):39-46. doi: 10.1016/j.jhep.2009.03.015. Epub 2009 Apr 23. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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